抑郁症患者静息态功能磁共振与睡眠结构研究

Resting-state Functional Magnetic Resonance Imaging and Sleep Structure Analyze in Depression

目的:研究抑郁症患者睡眠结构特征和静息态脑部活动特征。方法:选取首发单相抑郁症患者19例为病例组、体检健康者10例为对照组。两组均行静息态功能磁共振成像扫描(rfMRI)和睡眠脑电图检查,磁共振采用局部一致性法(ReHo)和低频振幅法(ALFF)分析,比较两组检查结果。结果:病例组睡眠潜伏期长于对照组,睡眠效率、N3期和REM期比例均低于对照组,N1、N2期比例高于对照组,比较差异均有统计学意义(P<0.05);与对照组相比,病例组左梭状回、左小脑后叶ReHo值降低,右顶上小叶、左楔前叶、右枕叶舌回ReHo值升高,右额叶直回、右枕叶舌回、左小脑后叶、右小脑前叶ALFF值降低,右楔叶ALFF值升高,比较差异均有统计学意义(P<0.05)。结论:伴睡眠障碍的首发单相抑郁症患者存在多区域脑功能异常。

Objective:To study the characteristics of sleep structure and resting brain activity in patients with depression.Method:A total of 19 patients with first-episode unipolar depression were selected as case group and 10 healthy persons as control group.Resting-state functional magnetic resonance imaging(rfMRI)and sleep electroencephalogram were performed in both groups,and ReHo and ALFF were used for magnetic resonance analysis.The results of two groups were compared.Result:The sleep latency of case group was longer than that of control group,sleep efficiency,the proportion of N3 and REM stages were lower than those of control group,and the proportion of stage N1 and N2 was higher than that of control group,the differences were statistically significant(P<0.05).Compared with the control group,the ReHo values of left fusiform gyrus and left posterior cerebellar lobe decreased,the ReHo values of right superior parietal lobe,left precuneus and right occipital lobe lingual gyrus increased,the ALFF values of right frontal lobe straight gyrus,right occipital lobe lingual gyrus,left posterior cerebellar lobe and right anterior cerebellar lobe decreased,and the ALFF values of right cuneus increased,the differences were statistically significant(P<0.05).Conclusion:Patients with first-episode unipolar depression with sleep disorders have multiple regional brain dysfunction.