静脉回流曲线解读冻干重组人脑利钠肽的研究进展及对心力衰竭患者血流动力学参数的影响

Venous Reflux Curve Interpretation of Lyophilized Recombinant Human Brain Natriuretic Peptide and Its Effect on Hemodynamic Parameters in Patients with Heart Failure

目的:探讨分析静脉回流曲线解读冻干重组人脑利钠肽的研究进展及对心力衰竭患者血流动力学参数的影响。方法:选择2016年5月-2018年5月于本院心血管内科治疗的70例心力衰竭患者,按照随机数字表法分为对照组和研究组,各35例。对照组患者进行常规治疗,研究组在常规治疗的基础上使用冻干重组人脑利钠肽,比较两组的治疗效果,治疗前和治疗后IL-6、CRP、TNF-α等炎性因子的变化。记录患者两条静脉回流曲线之间输入冻干重组人脑利钠肽前后SV、CO、CI、EF等血流动力学参数的变化。结果:治疗后,研究组总有效率为97.1%,显著高于对照组的71.1%(P<0.05);研究组炎性因子指标均优于对照组(P<0.05)。治疗后,两组的SV、CO、CI、EF、Pms、PRA、RV均高于治疗前,差异均有统计学意义(P<0.05),且研究组SV、CO、CI、EF均高于对照组,Pms、PRA、RV均低于对照组,差异均有统计学意义(P<0.05)。结论:静脉回流曲线比较清晰地解读冻干重组人脑利钠肽对心力衰竭患者血流动力学参数的影响,使用冻干重组人脑利钠肽对患者的血流动力学参数的影响较大,且具有良好的治疗效果,可减轻心脏前负荷,改善心肌重构。

Objective:To investigate the progress of venous return curve interpretation of Lyophilized Recombinant Human Brain Natriuretic Peptide and its effect on hemodynamic parameters in patients with heart failure.Method:70 patients with heart failure who were treated in cardiovascular department of our hospital from May 2016 to May 2018 were selected,according to the random number table method,they were divided into control group and study group,35 cases in each group.The control group was treated with routine treatment,on the basis of routine treatment,the study group used Lyophilized Recombinant Human Brain Natriuretic Peptide.The therapeutic effects of the two groups,and the changes of inflammatory factors such as IL-6,CRP and TNF-α before and after treatment were compared between the two groups.Changes of hemodynamic parameters such as SV,CO,CI and EF before and after lyophilized recombinant human brain natriuretic peptide were recorded between two venous reflux curves.Result:After treatment,the total effective rate in the study group was 97.1%,which was significantly higher than 77.1% in the control group(P<0.05).The inflammatory factors in the study group were better than those in the control group(P<0.05).After treatment,the SV,CO,CI,EF,Pms,PRA,RV of both groups were higher than those before treatment,the differences were statistically significant(P<0.05);the SV,CO,CI,EF of the study group were higher than those of the control group,and the Pms,PRA,RV were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on hemodynamic parameters of patients with heart failure is clearly understood,the effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on hemodynamic parameters of patients is greater,and it has a good therapeutic effect,which can reduce the preload of the heart and improve the remodeling of myocardium.