阿托伐他汀钙对冠心病心力衰竭患者血管内皮损伤的影响研究

Effect of Atorvastatin Calcium on Vascular Endothelial Injury in Patients with Coronary Heart Disease and Heart Failur

目的:探讨阿托伐他汀钙对冠心病心力衰竭患者血管内皮功能及肱动脉血流介导的扩张反应影响。方法:选取本院2016年8月-2017年10月收治的冠心病心力衰竭患者40例作为研究对象,按照患者的自愿原则将其分为对照组和研究组,每组20例。对照组给予常规抗心力衰竭治疗,研究组在常规治疗的基础上加用阿托伐他汀钙口服治疗,观察比较两组治疗前后的血管内皮指标水平及肱动脉血流介导的扩张反应情况。结果:治疗后,两组一氧化氮(NO)、降钙素基因相关肽(CGRP)指标水平与治疗前比较均明显升高,内皮素(ET)指标水平均明显降低;且研究组NO、CGRP指标水平均明显高于对照组,ET指标水平明显低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组血管内径扩张程度为(9.2±5.4)%明显高于对照组的(7.4±5.5)%,差异有统计学意义(P<0.05)。结论:血管内皮功能障碍是冠心病心力衰竭患者的症状表现形式之一,阿托伐他汀钙片可以改善患者的血管内皮功能指标,缩小心腔径,治疗过程中安全性好,对疾病的恢复作用较为显著,具有重要的临床治疗价值。

Objective:To investigate the effect of Atorvastatin Calcium on vascular endothelial function and brachial artery flow mediated dilation in patients with coronary heart disease and heart failure.Method:A total of 40 patients with coronary heart disease and heart failure admitted in our hospital from August 2016 to October 2017 were selected as the research objects.According to the voluntary principle of patients,they were divided into control group and study group,20 cases in each group.The control group was given routine anti-heart failure treatment,the study group was given Atorvastatin Calcium orally on the basis of routine treatment.The levels of vascular endothelial parameters and brachial artery flow mediated dilation before and after treatment between the two groups were observed and compared.Result:After treatment,the levels of nitric oxide(NO)and calcitonin gene-related peptide(CGRP)in the two groups were significantly higher than those before treatment,the levels of endothelin(ET)were significantly lower than those before treatment;the levels of NO and CGRP in the study group were significantly higher than those in the control group,the levels of ET was significantly lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,the degree of dilatation of vascular inner diameter in the study group was(9.2±5.4)% significantly higher than(7.4±5.5)%in the control group,the difference was statistically significant(P<0.05).Conclusion:Vascular endothelial dysfunction is one of the manifestations of patients with coronary heart disease and heart failure.Atorvastatin Calcium Tablets can improve the vascular endothelial function of patients,reduce the diameter of the heart cavity and has good safety in the treatment process.It has a significant effect on the recovery of the disease and has important clinical therapeutic value.