基于数据挖掘技术研究治疗血管性痴呆方剂的组方配伍规律

Analysis on Composition Rules of Prescription for the Treatment of Vascular Dementia Based on the Data Mining Technique

目的:基于中医传承辅助平台(V2.5)软件分析期刊与专利文献中治疗血管性痴呆(VD)方剂的组方用药规律。方法:筛选中国期刊全文数据库(CNKI)、维普期刊资源整合服务平台(VIP)、万方数据知识服务平台(Wangfang)和国家知识产权局专利检索与分析数据库(Patent Search and Analysis of SIPO)中近5年治疗VD的方剂,通过中医传承辅助平台(V2.5)软件构建方剂数据库,利用该软件集成的关联规则及熵聚类等数据挖掘算法,总结治疗VD方剂中的用药频次、常用药对、潜在药对及发现新方。结果:通过对155首治疗VD方剂所含药物的频次统计分析,得到治疗VD的常用药物19味,其中远志、黄芪、丹参、川芎和石菖蒲五味药物的使用频次最高;使用频次较高的药对有19个,其中川芎与石菖蒲、远志与石菖蒲、黄芪与石菖蒲配伍位居前3位;通过熵层次聚类分析算法发现关联系数较高的潜在药对26个及潜在新方13个。结论:CNKI、VIP、Wanfang、Patent Search and Analysis of SIPO中收录治疗VD的方剂多以活血化瘀、化痰开窍的药物为主,以益气安神、补肝益肾的药物为辅,挖掘得到的新方具有潜在的临床应用和新药开发价值。

Objective:Based on the software of Traditional Chinese Medicine Inheritance Assistance Platform(V2.5),to analyze the regularity of prescription medication for vascular dementia(VD)in periodicals and patent literature.Method:Screening of Chinese journal full-text database(CNKI),VIP journals resource integration service platform(VIP),Wanfang Data Knowledge Service Platform(Wanfang)and Patent Search and Analysis of SIPO in nearly five years prescriptions for treatment of VD.Through the Traditional Chinese Medicine Inheritance Assistance Platform (V2.5) to build prescription database,using the software integration and entropy clustering data mining association rules algorithm,summarizes the treatment of vascular dementia drug use frequency of the prescriptions,commonly used medicines,potential drugs,and found the new prescriptions.Result:Through statistical analysis of the frequencies of 155 prescriptions for VD,19 commonly used drugs for VD were obtained,among which Polygala tenuifolia,Astragalus membranaceus,Salvia miltiorrhiza,Ligusticum Chuanxiong and Acorus tatarinowii had the highest frequencies.19 pairs of medicines were used more frequently,among which Chuanxiong and Acorus tatarinowii,Polygala tenuifolia and Acorus tatarinowii,Astragalus membranaceus and Acorus tatarinowii were the top three.Entropy hierarchical clustering analysis was used to find 26 potential drugs with high correlation coefficient and 13 potential new drugs.Conclusion:The prescriptions for VD were included in CNKI,VIP,Wanfang,Patent Search and Analysis of SIPO,most of them are drugs for activating blood circulation to dissipate blood stasis and dissipating phlegm for resuscitation,supplemented by drugs for benefiting qi for tranquillization and tonify the liver and kidney,the new discoveries have potential clinical applications and new drug development values.