膀胱癌患者化疗前后β_2-MG、CYFRA21-1和SCC-Ag水平的检测及意义

The Clinical Significance of SCC-Ag,CYFRA21-1 and β_2-MG in Patients with Bladder Cancer

目的探讨膀胱癌患者化疗前后β_2-MG、CYFRA21-1和SCC-Ag水平的检测及意义。方法选择2015年1月至2017年1月于我院就诊的60例膀胱癌患者作为观察组,同时选取同期我院60例健康体检者作为对照组,比较各组SCC-Ag、CYFRA21-1,β_2-MG水平变化。结果与对照组相比,观察组患者治疗前SCC-Ag水平较高,差异具有统计学意义(P <0. 05);与治疗前相比,观察组治疗后患者SCC-Ag水平降低,差异具有统计学意义(P <0. 05)。与对照组相比,观察组患者治疗前CYFRA21-1水平较高,差异具有统计学意义(P <0.05);与治疗前相比,观察组治疗后患者CYFRA21-1水平降低,差异具有统计学意义(P <0.05)。与对照组相比,观察组患者治疗前β_2-MG水平较高,差异具有统计学意义(P <0. 05);与治疗前相比,观察组治疗后患者β_2-MG水平降低,差异具有统计学意义(P <0. 05)。结论膀胱癌患者中SCC-Ag、CYFRA21-1,β_2-MG指标水平比正常人群高,治疗后其水平降低,SCC-Ag、CYFRA21-1,β_2-MG可用于间接反映膀胱癌患者的疾病预后情况。

Objective To evaluate the clinical significance of levels of SCC-Ag,CYFRA21-1 and β2-MG in patients with bladder cancer. Methods 60 cases patients with bladder cancer in our hospital from January 2015 to January 2017 were enrolled into the observation group,60 healthy people were also chosen as the normal control group.The levels of SCC-Ag,CYFRA21-1 and β2-MG were evaluated in both groups. Results Compared to the control group,the levels of SCC-Ag in the observation group were significantly higher( P <0.05).Compared to the pretreatment,the levels of SCC-Ag in the observation group were significantly lower after the treatment (all P <0.05).Compared to the control group,the levels of CYFRA21-1 in the observation group were significantly higher ( P <0.05).Compared to pretreatment,the levels of CYFRA21-1 in the observation group were significantly lower after the treatment ( P <0.05).Compared to the control group,the levels of β2-MG in the observation group were significantly higher.( P <0.05).Compared to the pretreatment,the levels of β2-MG in the observation group were significantly lower after the treatment ( P <0.05). Conclusion The levels of SCC-Ag,CYFRA21-1 and β2-MG in patients with bladder cancer are higher than the healthy people,but these differences decrease after the treatment.Levels of SCC-Ag,CYFRA21-1 and β2-MG can reflect the prognosis of patients with bladder cancer.