乳腺癌患者发生前哨淋巴结转移与年龄、肿瘤直径及血清CA153水平等的相关性研究

Correlations Among Sentinel Lymph Node Metastasis and Ages,Tumor Diameters and the Serum CA153 Levels in Patients with Breast Cancer

目的探究原发性乳腺癌患者发生前哨淋巴结转移(sentinel lymph node metastasis,SLNM)的可能危险因素。方法选择从2016年10月至2017年10月期间在本医院住院的原发性乳腺癌患者200例。术中行前哨淋巴结活检(sentinel lymph node biopsy,SLNB),根据活检结果将患者分为SLNB组与无SLNB组。术后测量并记录每组患者切除的肿瘤直径。分析患者年龄、BMI、肿瘤直径、肿瘤所在象限及血清CA153水平与SLNM的相关性。结果 200例乳腺癌患者中,43例发生SLNM,157例未发生SLNM。单因素分析表明,年龄、肿瘤直径、肿瘤所在象限与血清CA153水平均与SLNM有关(P <0.05)。多因素分析显示,年龄、肿瘤直径与血清CA153水平是影响乳腺癌SLNM的独立危险因素(P <0.05)。结论患者年龄、肿瘤直径与血清CA153水平是影响乳腺癌SLNM的独立危险因素,可作为临床实践参考指标。

Objective To explore the possible risk factors for the occurrence of sentinel lymph node metastasis in patients with primary breast cancer. Methods 200 patients whowere diagnosed primary breast cancer and hospitalized in our hospital from October 2016 to October 2017 were selected.Sentinel lymph node biopsy (SLNB)was performed during the operation foreach patient,and the patients were assigned tothe SLNB group and the non-SLNB group according to the biopsy results.The diameter of the excised tumor from each patient was measured and recorded after the operation.Correlations among SLNM and the ages,BMI’s,tumor diameters and positionsand serum CA 153 levels were analyzed. Results Out of the 200 patients with breast cancer,43 patients had SLNM,and 157 patients had no SLNM.Univariate analysis indicated thatage,tumor diameter,tumor quadrant and serum CA153 level were related to SLNM,respectively ( P <0.05).Multifactor analysis revealed that age,tumor diameter and serum CA153 level were independent risk factors affecting SLNM of breast cancer( P <0.05). Conclusion Age,tumor diameter and serum CA153 level were independent risk factors affecting SLNM of breast cancer,which can be used as a reference in clinical practice.