血栓通注射液联合阿司匹林治疗老年急性脑梗死患者的疗效分析

Efficacy Analysis of Xueshuantong Injection Combined with Aspirin in the Treatment of ElderlyPatients with Acute Cerebral Infarction

目的:观察血栓通注射液联合阿司匹林治疗老年急性脑梗死(ACI)患者的临床效果。方法:选取本院2017年1月-2018年1月住院治疗的老年急性脑梗死患者70例作为研究对象,按照随机数字表法将其分为对照组和观察组,各35例。对照组采用常规治疗措施基础上加用阿司匹林肠溶片,观察组在对照组治疗的基础上加用血栓通注射液,观察比较两组的临床疗效、治疗前后的血清炎性细胞因子表达水平及血液流变学指标情况。结果:观察组的治疗总有效率为94.29%明显高于对照组的77.14%,差异有统计学意义(X^2=4.172,P=0.022)。治疗前两组血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)炎性细胞因子表达及血液流变学指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组上述指标与治疗前比较均明显降低,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。结论:血栓通注射液联合阿司匹林不但可明显提高老年ACI患者的临床疗效,还可减轻脑组织炎症反应和改善血液流变学状态。

Objective:To observe the clinical efficacy of Xueshuantong Injection combined with Aspirin in the treatment of elderly patients with acute cerebral infarction(ACI).Method:A total of 70 elderly patients with acute cerebral infarction hospitalized in our hospital from January 2017 to January 2018 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with Aspirin Enteric-coated tablet on the basis of routine treatment,the observation group was treated with Xueshuantong Injection on the basis of the control group.The clinical efficacy,serum inflammatory cytokines expression level and hemorheological parameters before and after treatment between the two groups were observed and compared.Result:The total effective rate of the observation group was 94.29%,which was significantly higher than 77.14%of the control group,the difference was statistically significant(χ^2=4.172,P=0.022).There were no significant differences in the levels of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)inflammatory cytokines expression and hemorheological parameters between the two groups before treatment(P >0.05).After treatment,the above indexes in the two groups were significantly lower than those before treatment,and the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Xueshuantong Injection combined with Aspirin can not only significantly improve the clinical efficacy of elderly patients with ACI,but also reduce the inflammation of brain tissue and improve the state of hemorheology.