奶牛乳腺炎致病机制的表观遗传调控研究进展

Progress on Epigenetic Regulation of the Pathogenesis of Cow Mastitis

奶牛乳腺炎作为制约奶牛养殖业发展的主要疾病之一,其受到环境、理化因素以及不同病原菌等多种因素影响。表观遗传调控作为一种新的分子调控机制,在奶牛乳腺炎致病过程中起着十分重要的作用。本文拟从DNA甲基化、组蛋白修饰和非编码RNA等多方面综述其在奶牛乳腺炎发生、发展中的作用,并从多维度提出奶牛乳腺炎表观遗传调控机制未来研究策略,以期为奶牛乳腺炎致病机制研究以及有效防控提供参考。

As one of the main diseases that impede the development of dairy cattle farming industry,cow mastitis is deeply influenced by environmental,physicochemical factors and different pathogenic bacteria.Epigenetic regulation,being a new molecular regulation mechanism,plays a very important role in the pathogenesis of cow mastitis.Here,the roles of DNA methylation,histone modification and non-coding RNA in the occurrence and development of cow mastitis were reviewed,and the future research strategies of the epigenetic regulation mechanism of cow mastitis were proposed in multi-dimension,in order to provide references for the pathogenesis research and effective prevention and control of cow mastitis.