脂质体药物微粒的共焦显微拉曼光谱鉴别

Identification of liposomal drug particles by confocal Raman spectroscopy

雷公藤红素为雷公藤的根皮当中提取而来的抗癌活性成分,利用共焦显微拉曼光谱仪无损快速地检测了脂质体包裹的雷公藤红素药物微粒,并与空白脂质体微粒、单纯雷公藤红素的拉曼光谱进行对比,可以看出,药物经脂质体包裹后,仍可以在光谱中进行清晰识别的情况,为后续研究奠定基础.

Celastrol was a kind of anti-tumor active ingredient extracted from tripterygium wilfordii root and cortex,liposome was relatively mature as drug carrier of application,this paper used the confocal micro Raman spectroscopy non-destructive to detect celastrol packaged by liposome quickly and scathelessly,The Raman spectrum with the blank liposome's and celastrol's had been compared.It can be seen from these Raman spectra,liposomal celastrol still can be clearly identify in the spectrum,which had provided some ways and means for future research of celastrol.