长期服用阿司匹林的脑卒中患者再次复发的影响因素分析

Analysis of influencing factors for the recurrence of stroke patients with long-term aspirin intake

目的探讨长期服用阿司匹林脑卒中患者再次复发的影响因素,为患者治疗提供依据。方法选取2016年5月至2017年5月我院神经内科收治的缺血性脑卒中长期服用阿司匹林的患者120例为研究对象,将首次发生脑卒中且1年内无再次复发的患者60例为A组,将发生脑卒中≥2次患者60例为B组,两组均跟踪随访1年,采用logistic回归分析确定患者多次复发的影响因素。结果 B组患者吸烟、缺乏锻炼、晚上服药、餐前服药、间断服药明显多于A组,两组比较差异有统计学意义(P <0. 05);两组性别、年龄、用药剂量、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高血压等方面比较差异无统计学意义(P> 0. 05);logistic回归分析显示,吸烟、缺乏锻炼、晚上服药、餐前服药、间断服药是服用阿司匹林脑卒中患者再次复发的独立危险因素。结论吸烟、缺乏锻炼、晚上服药、餐前服药、间断服药是长期服用阿司匹林脑卒中患者再次复发的独立危险因素。

Objective To explore the influencing factors for the recurrence of stroke patients with long-term aspirin,and to provide evidence for patient treatment.Methods A total of 120 patients who took long-term aspirin for ischemic stroke admitted to our hospital from May 2016 to May 2017 were selected as the study subjects.The 60 patients with first stroke and no recurrence within 1 year were selected as the group A,while the 60 patients with stroke≥2 times were selected as the group B.Both groups were followed up for 1 year.Logistic regression analysis was used to determine the influencing factors of multiple recurrence.Results In the group B,smoking,lack of exercise,taking medication at night,taking medication before meals,and taking intermittent medication were significantly more than those in the group A,and the difference between the two groups was statistically significant(P<0.05).There were no statistical significant differences in comparison of gender,age,dosage,triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and hypertension between the two groups(P >0.05).Logistic regression analysis showed that smoking,lack of exercise,taking medication at night,taking medication before the meal,and intermittent medication were independent risk factors for recurrence of stroke patients with aspirin intake.Conclusion sSmoking,lack of exercise,taking medication at night,taking medication before meal,and intermittent medication are independent risk factors for recurrence of stroke patients with long-term aspirin intake.