消渴Ⅱ号方对早期糖尿病肾病血糖、UAER、Cys-c、HCY的影响

Effectof Xiaoke formula Ⅱ on blood glucose,UAER,Cys-c and HCY of early diabetic nephropathy

目的:观察自拟消渴Ⅱ号方治疗早期糖尿病肾病的临床疗效。方法:选择86例2型糖尿病肾病患者,Mo gensen分期为糖尿病肾病早期,随机分为对照组40例、治疗组46例,两组均予二甲双胍或拜糖平或(和)胰岛素治疗,对照组加用厄贝沙坦口服,每日1次,每次1片;治疗组在对照组基础上加用自拟消渴Ⅱ号方治疗,12周为1个疗程。结果:两组治疗后总有效率比较有显著性差异(P﹤0.01)两组患者治疗后FPg、UAER、Cys-c、HCY、LDL-C、TC比较均较治疗前明显下降,且治疗组UAER、Cys-c、HCY下降幅度优于对照组。结论:消渴II号方可降低早期糖尿病肾病患者UAER、Cys-c、HCY指标,能提高西药常规治疗该病的总有效率。

Objective:To observe the clinical effectof self-made Xiaoke formula Ⅱon early diabetic nephropathy.Methods:86 cases of selected patients with type 2 diabetic nephropathy,who were staged as early diabetic nephropathy by Mogensen,were randomly divided into treatment group and control group,40 cases in control group,46 cases in treatment group.Both groups were treated with metformin or acarbose or insulin.The control group was treated plus with irbesartan on the basis of basic treatment,orally,once a day,1 tablet each time;while the treatment group was treated pluswith self-made Xiaoke formulaⅡon the basis of treatment of control group.12 weeks as a course of treatment.Results:Compared between two groups before and after treatment,there was a significant difference in total effective rate(P<0.01).Compared between two groups after treatment,FPG,UAER,Cys-c,HCY,LDL-C and TC of patients were significantly lower than before treatment,and the degree of reduction of UAER,Cys-c and HCY in treatment group was better than thatin control group.Conclusion:Xiaoke formulaⅡcan reduce the indexes of UAER,Cys-c and HCY in patients with early diabetic nephropathy,and enhance the total effective rate of treating this disease with conventional western medicine.