首发强迫障碍患者静息状态下大脑自发活动及功能连接的研究

Study on spontaneous brain activity and functional connection in patients with first episode obsessive-compulsive disorder under resting-state

目的:探讨首次发作的强迫障碍患者静息状态下大脑自发活动及功能连接(FC)特点。方法:对20例首发强迫障碍患者(患者组)和20名性别、年龄相匹配的正常对照者(对照组)进行静息态功能磁共振扫描(f MRI),计算0. 01～0. 08 Hz频段内脑区低频振幅比率(f ALFF值);以左侧缘上回为兴趣区做全脑FC;采用f ALFF及FC分析方法并进行基于全脑体素的统计分析。结果:与对照组相比较,患者组左侧眶部额中回、右侧枕中回、左侧楔叶f ALFF显著降低(P均<0. 005,cluster> 20),左侧小脑角下、左侧缘上回f ALFF显著增高(P均<0. 005,cluster> 20);左侧缘上回与右侧缘上回、右侧顶上回和右侧中央后回FC明显增强(P均<0. 005)。结论:首发强迫障碍患者在静息状态下存在多个脑区自发神经活动及FC异常,可能与首发强迫障碍的核心症状有关。

Objective:To explore the spontaneous brain activity and functional connection(FC)in patients with first episode obsessive-compulsive disorder(OCD)under resting-state.Method:A resting-state functional magnetic resonance scan(fMRI)was performed on 20 OCD patients(case group)and 20 gender and age-matched control subjects(control group).The low-frequency amplitude ratio(fALFF)in the frequency range of 0.01-0.08 Hz of the brain region was calculated.The whole brain FC was performed on the left supramarginal gyrus as the region of interest,and the analysis method of fALFF and FC were used and the statistical analysis based on whole brain voxels was performed.Results:Compared with the control group,in the case group the fALFF value of the left middle orbital gyrus,the right middle occipital gyrus and the left cuneus were significant activated(all P<0.005,cluster >20),and the value of the left cerebral horn and left supramarginal gyrus were significantly increasing(all P<0.005,cluster >20);FC of the left and right supramarginal gyrus,right superior parietal gyrus and the right postcentral gyrus were significantly increased(all P<0.005).Conclusion:The first episode OCD patients have multiple spontaneous neuroactivity and FC abnormalities in the resting state,which may be related to the core symptoms of OCD.