以阴性症状为主的男性慢性精神分裂症患者血清白细胞介素-6、10及叶酸水平与认知功能的关系

Association of serum interleukin-6,-10,folic acid and cognitive function in male chronic schizophrenic patients with mainly negative symptoms

目的:探讨以阴性症状为主的男性慢性精神分裂症患者血清白细胞介素(IL)-6、IL-10及叶酸水平及其与神经认知功能的相关性。方法:采用阴性症状评定量表(SANS)、连线测验(TMT)、定步调连续加法任务测验(PASAT)、Stroop测验评估60例以阴性症状为主的男性慢性精神分裂症患者(患者组)病情及认知功能;使用酶联免疫吸附法(ELISA)检测其血清IL-6、IL-10和叶酸水平;结果与55名健康对照者(对照组)比较;分析患者血清IL-6、IL-10及叶酸水平与认知功能及病情的关系。结果:与对照组比较,患者组TMT、PASAT、Stroop成绩显著低下(P均<0. 01);血清IL-6水平显著升高(P <0. 05),IL-10及叶酸水平显著降低(P均<0. 01);患者组血清IL-6水平与TMT-B时间呈正相关(P <0. 05),IL-10水平与Stroop测验、PASAT评分呈正相关,与TMT时间及SANS总分呈负相关(P <0. 05或P <0. 01);血清叶酸水平与认知功能测验结果及SANS总分不相关。结论:以阴性症状为主的男性慢性精神分裂症患者存在免疫功能异常、叶酸降低和广泛认知功能障碍;血清IL-10水平可能是其潜在的生物学标记物之一。

Objective:To study the levels of serum interleukin(IL)-6,IL-10,folic acid and neurocognitive function in male chronic schizophrenic patients with mainly negative symptoms,and the correlations among them.Method:The condition and neurocognitive function of 60 male chronic schizophrenic patients with mainly negative symptoms(case group)were assessed by scale for assessment of negative symptoms(SANS),trail making test(TMT),paced auditory serial addition task(PASAT);and their serum IL-6,IL-10 and folic acid levels in all subjects were detected by enzyme linked immunosorbent assay(ELISA).The results were compared with 55 normal controls(control group).Results:Compared to the control group,the results of neurocognitive test(TMT,PASAT,Stroop)in the case group were significantly lower(all P<0.001);the serum IL-6 level was remarkabely increased(P<0.05)and IL-10 and folic acid levels were remarkabely decreased(all P<0.001).In the case group,the serum IL-6 level was positively correlated with time of TMT-B(P<0.05),IL-10 level was positively correlated with scores of Stroop test and PASAT(P<0.05 or P<0.01),and negatively correlated with times of TMT and total score of SANS(P<0.05 or P<0.01).The serum folic acid level was not correlated with all the results of cognitive tests and total scores of SANS.Conclusion:The male chronic schizophrenic patients with mainly negative symptoms have immune dysfunction,lower serum folic acid level and extensive cognitive impairment.Serum IL-10 may be a potential biological marker for negative symptoms.