阿托伐他汀联合苯扎贝特对急性冠脉综合征的疗效被引量：2

下载PDF

导出

摘要目的研究并探讨阿托伐他汀联合苯扎贝特对急性冠脉综合征(ACS)的疗效。方法选取2014年1月至2017年5月尉氏县中医院收治的120例ACS患者为研究对象。对照组患者口服阿托伐他汀,观察组患者口服阿托伐他汀和苯扎贝特治疗,两组均连续治疗3个月。治疗3个月后,比较两组临床疗效。比较两组治疗期间不良反应发生率。比较治疗前后两组患者血脂指标、血清炎症因子水平。结果对照组治疗总有效率为85.00%(51/60),观察组为96.67%(58/60),观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。对照组不良反应总发生率为8.33%(5/60),观察组为5.00%(3/60),两组不良反应总发生率相比,差异无统计学意义(P>0.05)。治疗后,观察组患者血清总胆固醇(TC)、甘油三酯(TG)水平均低于对照组,差异无统计学意义(均P<0.05)。治疗后,观察组患者血清C反应蛋白(CRP)、白细胞介素-6(IL-6)水平均低于对照组,差异无统计学意义(均P<0.05)。结论阿托伐他汀联合苯扎贝特可有效提高ACS治疗效果,促进血脂水平的降低,抑制炎症反应。

作者陈晓兵

机构地区尉氏县中医院内科

出处《河南医学研究》 CAS 2019年第1期126-128,共3页 Henan Medical Research

关键词急性冠脉综合征阿托伐他汀苯扎贝特疗效

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献6

1杨敏,刘奇峰,蓝新平,林斌,丘睿业.他汀联合苯扎贝特对急性冠状动脉综合征患者的治疗优势分析[J].国际心血管病杂志,2016,43(2):127-128. 被引量：6
2急性冠脉综合征急诊快速诊疗指南[J].中华急诊医学杂志,2016,25(4):397-404. 被引量：570
3孟祥娟,许静,程爱娟.急性冠脉综合征患者血清高迁移率族蛋白B1的表达及阿托伐他汀干预治疗的影响[J].天津医药,2016,44(4):497-500. 被引量：17
4葛彦彦,马晓静,鹿克风,苑海涛.阿托伐他汀强化治疗对ACS患者PCI效果的改善作用及其机制[J].山东医药,2016,56(37):44-46. 被引量：5
5陆芳,张俊岭,牟丽娜,李勇,郑群.调脂药物对急性冠状动脉综合征血脂和高敏C反应蛋白及心室重构的影响[J].中华老年医学杂志,2017,36(6):647-649. 被引量：7
6郑跃,许岚,谈鹰,程震峰,卢孔杰,张川.急性冠状动脉综合征合并糖尿病患者阿托伐他汀联合苯扎贝特治疗的不良心血管事件分析[J].心电与循环,2016,35(1):29-31. 被引量：3

二级参考文献82

1Lopes RD, White JA, Tricoci P, et al. Age, treatment, and outcomes in high-risk non-ST-segment elevation acute coro- nary syndrome patients: insights from the EARLY ACS trial EJ]. Int J Cardiol, 2013,167(6) : 2580-2587.
2Miller M,Cannon CP, Murphy SA, et al. Impact of triglycer- ide levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE IT-TIMI 22 trial. [J]. J Am Coll Cardiol, 2008,51(7):724-730.
3Yoo JY, Park CJ, Kim KY, et al. Development of an activated carbon filter to remove NO2 and HONO in indoor air[J]. J Hazard Mater, 2015,289:184-189.
4van Diepen S, Bakal JA, Lin M, et al. Variation in critical care unit admission rates and outcomes for patients with acute coro- nary syndromes or heart failure among high- and low-volume cardiac hospitals [J]. J Am Heart Assoc,2015, 4(3) :e001708.
5Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) [J]. Eur Heart J, 2016, 37 (3) : 267-315. DOI: 10. 1016/j. rec. 2015. 10. 009.
6Nabi F, Chang SM, Xu J, et al. Assessing risk in acute chest pain : The value of stress myocardial perfusion imaging in patients admitted through the emergency department [ J]. J Nucl Cardiol, 2012, 19 (2): 233-243. DOI: 10. 1007/s12350-011-9484-7.
7Shah BN, Balaji G, Alhajiri A, et al. Incremental diagnostic and prognostic value of contemporary stress echocardiography in a chest pain unit: mortality and morbidity outcomes from a real-world setting [J]. Cardiovasc Imaging, 2013, 6 (2): 202-209. DOI: 10. ll61/CIRCIMAGING. 112. 980797.
8Huhen E, Pickett C, Bittencourt MS, et al. Outcomes after coronary computed tomography angiography in theemergency department: a systematic review and meta-analysis of randomized, controlled trials [J]. J Am Coil Cardiol, 2013, 61 (8): 880- 892. DOI: 10. 1016/j. jacc. 2009. 02. 008.
9Mueller C, Giannitsis E, Christ M, et al. Multicenter evaluation of a 0-hour/l-hour algorithm in the diagnosis ofmyocardial infarction with high-sensitivity cardiac troponin T [ J ]. Ann Emerg Med, 2016, pii: S0196-0644 (15) 01501-2. DOI: 10. 1016/j. annemergrned. 2015. 11. 013.
10Reichlin T, Schindler C, Drexler B, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T [J]. Arch Intern Med, 2012, 172 (16) : 1211-1218. DOI: 10. 1001/archintemmed. 2012. 3698.