神经胶质细胞参与吗啡耐受机制及治疗的研究进展

Role of Glial Cells in Morphine Tolerance and Treatment

吗啡是临床上常用的强效镇痛药,然而长期应用会导致其镇痛效能降低,发生吗啡耐受。以往对吗啡耐受机制的研究主要集中在脊髓神经元敏化等中枢神经元机制,近年来越来越多的学者开始关注神经胶质细胞,特别是小胶质细胞和星形胶质细胞,在吗啡耐受形成中的作用。本文简要综述了神经胶质细胞参与吗啡耐受的作用机制及其治疗的研究进展,为解决临床上中重度疼痛治疗中的难点问题提供新的解决思路与依据。

Morphine is the most common potent analgesic for the treatment of severe pain.However,chronic administration of morphine would lead to the development of analgesic tolerance,and tolerance seriously inhibits the application of morphine in clinical medicine.To date,most studies on morphine tolerance have focused mainly on brain neurons.Recently,compelling evidences show that glia cells,especially microglia and astrocyte,also play a pivotal role.The article reviews the advances in the role of glia cells in the potential mechanisms and efficient treatments to morphine tolerance.