2-乙酰氨基-2-去氧-3,6-二-氧-苄基-α-D-吡喃葡萄糖烯丙基苷的合成工艺优化

Process Improvement on Synthesis of Allyl 2-Acetamido-2-deoxy-3,6-di-O-benzyl-α-D-glucopyranoside

以N-乙酰氨基葡萄糖为原料,经烯丙基化、苯亚甲基化、苄基化和选择性开环等4步反应,合成了2-乙酰氨基-2-去氧-3,6-二-氧-苄基-α-D-吡喃葡萄糖烯丙基苷,总收率53.4%,其结构经~1H NMR,^(13)C NMR和LC-MS(ESI)确证。

Allyl 2-acetamido-2-deoxy-3,6-di-O-benzyl-α-D-glucopyranoside was synthesized from N-acetyl-D-glucosamine via a four-step reaction of allylation,benzylidenation,benzylation and selective ring opening reaction with an overall yield of 53.4%.The structure of was confirmed by^1 H NMR,^13 C NMR and LC-MS(ESI).