百令胶囊联合二甲双胍对糖尿病肾病患者的临床疗效

Clinical effects of Bailing Capsules combined with metformin on diabetic nephropathy patients

目的探讨百令胶囊联合二甲双胍对糖尿病肾病患者的临床疗效。方法 94例患者随机分为观察组与对照组,每组47例,对照组给予二甲双胍,观察组在对照组基础上加用百令胶囊,疗程12周。然后,检测总有效率、24 h尿蛋白定量、UAER、HOMA-IR及Cr、BUN、FPG、Hb A1c、脂联素、血清炎性因子(IL-6、MCP-1、TNF-α)水平。结果观察组总有效率显著高于对照组(P<0. 05)。治疗后,2组24 h尿蛋白定量、UAER、HOMA-IR及Cr、BUN、FPG、Hb A1c水平显著降低(P<0. 05),以观察组更显著(P<0. 05);观察组脂联素、IL-6、MCP-1、TNF-α水平显著降低(P<0. 05),也显著低于对照组(P<0. 05)。结论百令胶囊联合二甲双胍可改善糖尿病肾病患者胰岛素抵抗和炎性反应,降低脂联素水平,具有重要临床意义。

AIM To explore the clinical effects of Bailing Capsules combined with metformin on diabetic nephropathy patients.METHODS Ninety-four patients randomly assigned into observation group and control group,47 cases in each group,went on 12-week intervention either of metformin(control group),or metformin+Bailing Capsules(observation group).Subsequently,total effective rate,24 h urine protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c,adiponectin,serum inflammatory factors(IL-6,MCP-1,TNF-α)levels were detected.RESULTS The observation group demonstrated significantly higher total effective rate than the control group(P<0.05).Both groups shared markedly decreased 24 h urinary protein quantity,UAER,HOMA-IR and Cr,BUN,FPG,HbA1 c levels after the treatment(P<0.05),especially for the observation group(P<0.05),which was observed with obviously decreased adiponectin,IL-6,MCP-1,TNF-αlevels(P<0.05),significantly lower in contrast to the control group(P<0.05).CONCLUSION Bailing Capsules combined with metformin highlights the clinical management of diabetic nephropathy patients through improving insulin resistance and inflammatory reaction,and reducing the level of adiponectin.