MMP-9、ERK与PTEN在舌癌组织中的表达及临床意义

Expressions and Clinical Significances of MMP-9,ERK and PTEN in Tongue Cancer Tissues

目的观察基质金属蛋白酶9(MMP-9)、细胞外信号调节激酶(ERK)与张力蛋白同源基(PTEN)在舌癌组织中的表达,探讨其临床意义。方法选择2012年5月—2018年6月秦皇岛市海港医院及秦皇岛市第四医院收治65例舌癌患者的术后病理组织为舌癌组,同时选取癌旁正常组织25例作为癌旁组织组。观察不同组织中MMP-9、ERK与PTEN表达情况,及其与临床病理学参数的关系。结果舌癌组ERK、MMP-9阳性表达率均高于癌旁组织组,PTEN低于癌旁组织组(P <0. 05)。临床分期越高、有淋巴结转移者的PTEN阳性表达越低、ERK阳性率越高(P <0. 05),临床分期越高、分化程度越低、有淋巴结转移者的MMP-9的阳性表达率越高(P <0. 05)。结论 MMP-9、ERK与PTEN可能参与舌癌发生与发展过程。

Objective To observe expressions of matrix metalloproteinase-9(MMP-9),extracellular signal-regulated kinase(ERK)and phosphate and tension homology deleted on chromosome ten(PTEN)in tongue cancer tissues and to study its clinical significances.Methods A total of 65 cases of postoperative pathological tissues from patients with tongue cancer admitted during May 2012 and June 2018 were selected as tongue cancer group,and 25 cases of normal tissues adjacent to tongue cancer tissues were simultaneously selected as para-cancerous tissue group.Expressions of MMP-9,ERK and PTEN in different tissues and their correlations with clinicopathological parameters were observed.Results In tongue cancer group,positive rates of ERK and MMP-9 were significantly higher,while positive rate of PTEN was significantly lower than those in para-cancerous tissue group(P<0.05).Positive rate of ERK could be higher when positive expression of PTEN was lower in patients with higher clinical stage and lymph node metastasis(P<0.05),and positive expression rate of MMP-9 could be higher in patients with higher clinical stage,lower degree of differentiation and lymph node metastasis.Conclusion MMP-9,ERK and PTEN may be involved in carcinogenesis and progression of tongue cancer.