支气管哮喘患儿血清Lyso-PC、apo B水平变化及其临床意义研究

Changes of serum Lyso-PC and apo B levels in children with bronchial asthma and their clinical significance

目的探讨支气管哮喘(BA)患儿血清溶血卵磷脂(Lyso-PC)、载脂蛋白B(apo B)水平变化及其临床意义。方法选取2015年3月至2018年3月本院收治的BA患儿100例,依据临床分期分为急性期组(n=36例)和缓解期组(n=64例),同期选取体检中心健康儿童50例作为健康组,检测所有儿童血清Ly-so-PC、apo B水平和肺功能[第1秒用力呼气容积(FEV_1)、呼气峰流速(PEF)]。结果急性期组血清Lyso-PC、apo B水平明显高于缓解期组,缓解期组血清Lyso-PC、apo B水平明显高于健康组,差异有统计学意义(P<0. 05);急性期组FEV_1、PEF明显低于缓解期组,缓解期组FEV_1、PEF明显低于健康组,差异有统计学意义(P <0. 05); Pearson相关性分析结果显示,血清Lyso-PC、apo B水平均与FEV_1、PEF呈负相关(P <0. 05)。结论血清Lyso-PC、apo B水平变化与BA的发生发展有关,Lyso-PC、apo B可能参与了患儿肺功能损害的病理过程。

Objective To discuss the changes of serum lyphosphatidylcholine(Lyso-PC)and apolipoprotein B(apo B)levels in children with bronchial asthma(BA)and their clinical significance.Methods 100 children with BA were selected from March 2015 to March 2018 in our hospital.According to clinical stages,they were divided into the acute phase group(n=36)and the remission group(n=64),and 50 healthy children were selected as the health group at the same time in medical examination center.Their serum Lyso-PC and apo B levels and lung function(FEV 1 and PEF)were detected in all children.Results The serum Lyso-PC and apo B levels in the acute phase group were significantly higher than those in the remission group,and the serum Lyso-PC and apo B levels in the remission group were significantly higher than those in the healthy group(P<0.05).The levels of FEV 1 and PEF in the acute phase group were significantly lower than those in the remission group,and they were significantly lower in the remission group than in the healthy group(P<0.05).The Pearson correlation analysis showed that the serum Lyso-PC and apo B levels were negatively correlated with FEV 1 and PEF(P<0.05).Conclusion The changes of serum Lyso-PC and apo B levels are related to the occurrence and development of BA,and Lyso-PC and apo B may be involved in the pathological process of lung function impairment in children.