基于析因设计的中药熏蒸治疗血热型银屑病研究

Clinical study on herbal steaming therapy in treating psoriasis of blood-heat type based on factorial design

[目的]通过析因设计探究中药熏蒸治疗血热型银屑病的临床疗效。[方法]按两因素三水平的析因设计方法进行分析,两因素即温度组、时间组,三水平即温度组(38、40、42℃)、时间组(20、25、30 min),采集90例住院患者,随机分为9组进行试验,疗程均为2周。[结果]不同温度、时间组合对中药熏蒸治疗血热型银屑病的疗效影响大小为:42℃×25 min>42℃×30 min>42℃×20 min>40℃×25 min>40℃×20 min>38℃×30 min>40℃×30 min>38℃×20 min>38℃×25 min。在时间与温度的交互作用统计分析结果中,提示时间、温度之间的交互作用无统计学意义(P>0.05),但就温度的单独效应结果来看,差异有统计学意义(P<0.05),即不同的温度对银屑病面积与严重性指数(PASI)评分下降值具有显著影响。进一步分析,42℃温度条件下对PASI评分降低影响更为显著。[结论]中药熏蒸对血热型银屑病有良好的治疗效果,42℃×25 min组合的疗效明显优于其他组合,且无明显不良反应。

[Objective]To explore the clinical effects of herbal steaming therapy in treating blood-heat-type psoriasis based on factorial design.[Methods]Totally 90 patients were randomly divided into 9 groups to conduct a two-factor(temperature,time)three-level(temperature:38 ℃,40 ℃,42 ℃;time:20 min,25 min,30 min)factorial design.[Results]Combined the factor of temperature with time,there are different effect in treating blood-heat-type psoriasis with herbal steaming therapy:42 ℃×25 min >42 ℃×30 min >42 ℃×20 min >40 ℃×25min >40 ℃×20 min >38 ℃×30 min >40 ℃×30 min >38 ℃×20 min >38 ℃×25 min.The interaction of the statistical analysis results between time and temperature has no statistical significance(P >0.05).However,there is statistical significance(P<0.05)considering the single effect of temperature which means different value of temperature has remarkable influence on the decreasing PASI score.Furthermore,the PASI score decreases significantly when the temperature at 42 ℃.[Conclusion]In treating blood-heat-type psoriasis with herbal steaming therapy,the group of 42 ℃×25 min produces the highest curative effect and without any side effect.