阿立哌唑联合认知干预对精神分裂症患者认知功能及生活质量的影响

Effect of aripiprazole combined with cognitive intervention on cognitive function and quality of life in patients with schizophrenia

目的观察阿立哌唑联合认知干预对精神分裂症患者认知功能及生活质量的影响。方法选择2015年1月～2017年12月在我院接受透析治疗的精神分裂症患者80例作为研究对象,采用随机数字表法将患者分为对照组和观察组,各40例,两组均予阿立哌唑治疗,连续治疗8周,治疗期间不得使用其他抗精神病药物。同时观察组联合认知干预,比较两组治疗后的临床疗效、MMSE评分、PSP评分及生活质量各项评分的变化情况。结果治疗后,观察组的总有效率达97.50%,明显高于对照组,两组疗效比较,差异具有显著性(P<0.05)。治疗后,观察组与对照组患者的MMSE评分、PSP评分明显高于治疗前,且观察组患者治疗后的MMSE评分、PSP评分明显高于对照组,两组比较,差异具有显著性(P<0.05)。治疗前观察组与对照组患者的角色功能、躯体功能、认知功能、社会功能、总健康状况评分比较,差异无统计学意义(P>0.05);治疗后观察组与对照组患者的角色功能、躯体功能、认知功能、社会功能、总健康状况评分明显高于治疗前及对照组,差异具有显著性(P<0.05)。结论阿立哌唑联合认知干预有利于提高精神分裂症患者的认知功能及生活质量,值得广泛推广和应用。

Objective To observe the effect of aripiprazole combined with cognitive intervention on cognitive function and quality of life in the patients with schizophrenia.Methods 80 patients with schizophrenia who were given hemodialysis in our hospital from January 2015 to December 2017 were selected as study subjects.Patients were divided into control group and observation group by random number table method,with 40 cases in each group.?Both groups were treated with aripiprazole for 8 weeks.No other antipsychotic drugs may be used during treatment.At the same time,the observation group was given combined cognitive intervention.The changes in clinical efficacy,MMSE scores,PSP scores,and quality of life scores were compared between the two groups after treatment.Results After treatment,the total effective rate in the observation group was 97.50%,which was significantly higher than that in the control group.The difference between the two groups was significant(P<0.05).After treatment,the MMSE score and PSP score in the observation group and control group were significantly higher than those before treatment.In the observation group,the MMSE score and PSP score after treatment were significantly higher than those in the control group.The differences between the two groups were significant(P<0.05).Before treatment,there were no statistically significant differences in the role function,physical function,cognitive function,social function,and total health score between the observation group and the control group(P >0.05);after treatment,the scores of role function,physical function,cognitive function,social function,and total health conditions in the observation group and the control group were significantly higher than those before treatment and in the control group.The differences were significant(P<0.05).Conclusion Aripiprazole combined with cognitive intervention is beneficial to improving the cognitive function and quality of life of patients with schizophrenia,which is worthy of extensive promotion and application.