无创呼吸机联合管道雾化吸入治疗急性左心衰竭的疗效观察

Therapeutic effect of non-invasive ventilator combined with pipeline atomization inhalation in the treatment of acute left heart failure

目的探讨无创呼吸机联合管道雾化吸入治疗急性左心衰竭的临床疗效。方法 2016年4月～2018年3月在开平市中心医院急诊科就诊的80例急性左心衰竭患者,随机分为对照组和治疗组,各40例。两组均给予常规治疗,如吸氧、强心、利尿、扩血管、平喘、改善循环、对症支持等,治疗组在常规治疗基础上加用无创呼吸机联合管道雾化吸入普米克令舒。两组均连续治疗至患者症状缓解,比较治疗前后临床症状、N-末端脑钠肽前体(NT-proBNP)、左室射血分数(LVEF)和左室舒张期E峰/A峰(E/A)比值、心率(HR)、呼吸频率(RR)、氧分压(PaO2)、氧饱和度(SatO2)、氧合指数(PaO2/FiO2)、症状缓解时间等。结果各组治疗后治疗组治疗效果较对照组更为明显(P<0.05)。结论无创呼吸机联合管道雾化吸入治疗急性左心衰竭比常规治疗临床效果更显著、更能缩短症状缓解时间、更能缩短病程、改善患者生活质量,并有良好的耐受性。

Objective To explore the clinical efficacy of non-invasive ventilator combined with pipeline atomization inhalation in the treatment of acute left heart failure.Methods Eighty patients with acute left heart failure who were admitted to the Emergency Department of Kaiping Central Hospital from April 2016 to March 2018 were randomly divided into two groups,the control group and the treatment group,40 cases in each group.Both groups were given routine treatment,such as oxygen inhalation,cardiotonic,diuretic,vasodilator,antiasthma,circulation improvement,symptomatic support,etc.The treatment group was additionally given non-invasive ventilator combined with pipeline atomization inhalation of Pulmicort on the basis of routine treatment.Both groups were treated continuously until the patient's symptoms were relieved.Clinical symptoms,N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left ventricular diastolic E peak/A peak(E/A)ratio,heart rate(HR),respiratory rate(RR),partial pressure of oxygen(PaO2),oxygen saturation(SatO2),oxygenation index(PaO2/FiO2),and time to symptom relief were compared.Results After treatment,the treatment effect of the treatment group was more obvious than that of the control group(P<0.05).Conclusion Non-invasive ventilator combined with pipeline atomization inhalation in treatment of acute left heart failure is more effective than conventional treatment,which can shorten the time of symptom relief,shorten the course of disease,improve the quality of life of patients,and have good tolerance.