三酰甘油水平对急性胰腺炎并发急性肾损伤的影响

Effect of triglyceride level on acute kidney injury complicating acute pancreatitis

【目的】探讨三酰甘油水平对急性胰腺炎患者并发急性肾损伤的影响。【方法】2015年1月—2017年3月,选择急性胰腺炎患者184例,根据患者入院时三酰甘油水平分为三酰甘油理想水平组(89例)、轻度升高组(53例)和重度升高组(42例),比较不同组患者急性肾损伤发生情况和病情严重程度。【结果】三酰甘油重度升高组的急性肾损伤发生率(33. 3%)、手术治疗率(16. 7%)、平均住院天数(20 d)和全身炎症反应综合征评分(3. 0)分别高于三酰甘油理想水平组的12. 3%、4. 5%、14 d和2. 3,差异均有统计学意义。校正年龄、性别、体质指数等影响因素后,入院时三酰甘油重度升高者发生急性肾损伤的风险是三酰甘油理想水平组的2. 35倍(95%CI:1. 32～4. 29)。【结论】高三酰甘油水平可能是急性胰腺炎患者发生急性肾损伤的影响因素之一。

[Objective] To explore whether the triglyceride level is associated with incidence of acute kidney injury in patients with acute pancreatitis.[Methods] From Jan 2015 to March 2017,184 patients with acute pancreatitis were selected and divided in to 3 groups based on different triglyceride levels:ideal triglyceride group(n=89),mild high triglyceride group(n=53)and severe high triglyceride group(n=42).The incidence of acute kidney injury and its severity were compared between the three groups.[Results] The incidence of acute kidney injury in severe high triglyceride group was 33.3%,significantly higher than that in ideal triglyceride group(12.3%).The surgical treatment(16.7% vs 4.5%),average hospitalization days(20 days vs 14 days)and systemic inflammatory response syndrome score(3.0 vs 2.3)in severe high triglyceride group were higher than those in ideal triglyceride group,and all differences between the two groups were significant.After adjusting for factors such as age,sex,body mass index and other confounders,the risk of acute kidney injury occurring in severe high triglyceride group was 2.35 times that in ideal triglyceride group(95%CI:1.32-4.29).[Conclusion] High triglyceride level proves to be associated with high risk of acute kidney injury in patients with acute pancreatitis.