非瓣膜性心房颤动患者Hcy、血管紧张素Ⅱ与CH A2DS2-VASc评分的关系

Correlation between the Hcy,Angiotonin Ⅱ and CHA2DS2-VASc Scores of Patients with Nonvalvular Atrial Fibrillation

目的探讨非瓣膜性心房颤动患者同型半胱氨酸(Homocysteine,Hcy)、血管紧张素Ⅱ与CHADS2、CHA2DS2-VASc评分的关系。方法方便选择该院65例非瓣膜性心房颤动患者与65名健康志愿者(2016年1月—2018年5月),设置为观察组与对照组,比较血清同型半胱氨酸、血管紧张素Ⅱ、CHADS2评分、CHA2DS2-VASc评分,将患者分为低中危血栓风险组与高危血栓风险组,比较其血清同型半胱氨酸、血管紧张素Ⅱ。结果观察组的同型半胱氨酸(16.42±5.65)μmol/L、血管紧张素Ⅱ(60.83±11.75)ng/dL、CHADS2评分(1.76±0.82)分、CHA2DS2-VASc评分(1.69±0.78)分均高于对照组的(9.58±2.73)μmol/L、(37.45±8.29)ng/dL、(0.89±0.53)分、(0.92±0.50)分,差异有统计学意义(t=8.788、13.108、 7.184、6.700,P<0.05)。在CHADS2评分系统中,高危血栓风险组的同型半胱氨酸(18.03±3.15)μmol/L、血管紧张素Ⅱ(64.19±7.36)ng/dL均高于低中危血栓风险组的(14.87±2.27)μmol/L、(56.23±5.82)ng/dL,差异有统计学意义(t=4.670、4.858,P<0.05);在CHA2DS2-VASc评分系统中,高危血栓风险组的同型半胱氨酸(17.95±2.93)μmol/L、血管紧张素Ⅱ(63.85±6.74)ng/dL均高于低中危血栓风险组的(14.96±2.05)μmol/L、(57.02±5.38)ng/dL,差异有统计学意义(t=4.753、4.507,P<0.05)。结论血清同型半胱氨酸、血管紧张素Ⅱ作为辅助预测非瓣膜性心房颤动患者血栓风险的指标。

Objective To study the correlation between the Hcy,angiotonin II and CHA2DS2-VASc scores of patients with nonvalvular atrial fibrillation.Methods 65 cases of patients with nonvalvular atrial fibrillation and 65 cases of healthy volunteers in our hospital from January 2016 to May 2018 were selected as the observation group and the control group,and the serum homocysteine,angiotonin II,CHADS2 score,CHA2DS2-VASc score were compare between the two groups,and the patients were divided into the low-risk and middle-risk groups and high-risk thrombus risk group,and the serum homocysteine and angiotensin II were compared.Results The Hcy,angiotonin II,CHADS2 and CHA2DS2-VASc scores in the observation group were higher than those in the control group[(16.42±5.65)μmol/L,(60.83±11.75)ng/dL,(1.76±0.82)points,(1.69±0.78)points vs(9.58±2.73)μmol/L,(37.45±8.29)ng/dL,(0.89±0.53)points,(0.92±0.50)points],the different was statistically significant(t=8.788,13.108,7.184,6.700,P<0.05),and in terms of CHADS2 marking system,the homocysteine,angiotensin II in the high-risk thrombus group were higher than those in the low-risk and middle-risk thrombus groups[(18.03±3.15)μmol/L,(64.19±7.36)ng/dL vs(14.87±2.27)μmol/L,(56.23±5.82)ng/dL],the different was statistically significant(t=4.670,4.858,P<0.05);in terms of CHA2DS2-VASc marking system,the homocysteine and angiotonin II in the high-risk thrombus group were higher than those in the low-risk and middle-risk thrombus groups[(17.95±2.93)μmol/L,(63.85±6.74)ng/dL vs(14.96±2.05)μmol/L,(57.02±5.38)ng/dL],the different was statistically significant(t=4.753,4.507,P<0.05).Conclusion The Hcy and angiotonin II can be used as the indexes of adjunctive predication of thrombus risks of patients with nonvalvular atrial fibrillation.