大株红景天联合前列地尔治疗急性冠脉综合征的疗效及对血脂水平的影响

Therapeutic effect of Rhodiola grandiflora combined alprostadil on acute coronary syndrome and its influence on blood lipid levels

目的:研究大株红景天联合前列地尔治疗急性冠脉综合征(ACS)的疗效及对血脂水平的影响。方法:选择2016年7月～2017年9月我院收治的104例ACS患者。患者被随机均分为前列地尔组(在常规治疗基础上加用前列地尔注射液)和联合治疗组(在前列地尔组基础上加用大株红景天注射液),两组疗程均为2周。观察比较两组治疗前后LVEDd、LVEF,血脂:TC、TG、HDL-C、LDL-C、血清高敏C反应蛋白(hsCRP)、白介素6 (IL-6)、单核细胞趋化蛋白-1 (MCP-1)水平,以及治疗总有效率和不良反应发生率。结果:治疗2周后,联合治疗组总有效率显著高于前列地尔组(94.23%比78.85%),P=0.022。与治疗前比较,治疗2周后两组LVEDd、TC、TG、LDL-C、血清hsCRP、IL-6及MCP-1水平均显著降低,LVEF和HDL-C水平均显著升高,P<0.05或<0.01。与前列地尔组比较,联合治疗组治疗2周后LVEDd [(58.07±6.14)mm比(55.12±5.06)mm]、TC [(5.63±0.94)mmol/L比(4.75±0.81)mmol/L]、TG [(2.78±0.54)mmol/L比(2.16±0.47)mmol/L]、LDL-C [(3.28±0.57)mmol/L比(2.56±0.42)mmol/L]、血清hsCRP [(6.27±1.14)mg/L比(5.39±0.96)mg/L]、IL-6 [(7.85±1.47)ng/L比(6.82±1.30)ng/L]及MCP-1 [(113.74±19.62)ng/L比(94.36±16.58)ng/L]水平降低更显著,LVEF [(45.74±8.48)%比(50.78±8.34)%]和HDL-C水平[(2.36±0.52)mmol/L比(2.93±0.57)mmol/L]升高更显著,P均<0.01。治疗期间,两组不良反应发生率无显著差异,P=0.539。结论:大株红景天联合前列地尔治疗ACS疗效显著,能显著改善患者心功能,调节血脂代谢,降低体内炎症反应,值得临床推广应用。

Objective:To study therapeutic effect of Rhodiola grandiflora combined alprostadil on acute coronary syndrome(ACS)and its influence on blood lipid levels.Methods:A total of 104 ACS patients,who were treated in our hospital from Jul 2016 to Sep 2017,were selected,randomly and equally divided into alprostadil group(received alprostadil injection based on routine treatment)and combined treatment group(received Rhodiola grandiflora injection based on alprostadil group),both groups were treated for two weeks.LVEDd,LVEF,levels of blood lipid:TC,TG,HDL-C,LDL-C,serum high sensitive C reactive protein(hsCRP),interleukin 6(IL-6)and monocyte chemoattractant protein-1(MCP-1)before and after treatment,total effective rate and incidence of adverse reactions were observed and compared between two groups.Results:After two-week treatment,total effective rate of combined treatment group was significantly higher than that of alprostadil group(94.23%vs.78.85%),P=0.022.Compared with before treatment,after two-week treatment,there were significant reductions in LVEDd,levels of TC,TG,LDL-C,serum hsCRP,IL-6 and MCP-1,and significant rise in LVEF and HDL-C level in two groups,P﹤0.05 or﹤0.01.Compared with alprostadil group after two-week treatment,there were significant reductions in LVEDd[(58.07±6.14)mm vs.(55.12±5.06)mm],levels of TC[(5.63±0.94)mmol/L vs.(4.75±0.81)mmol/L],TG[(2.78±0.54)mmol/L vs.(2.16±0.47)mmol/L],LDL-C[(3.28±0.57)mmol/L vs.(2.56±0.42)mmol/L],serum hsCRP[(6.27±1.14)mg/L vs.(5.39±0.96)mg/L],IL-6[(7.85±1.47)ng/L vs.(6.82±1.30)ng/L]and MCP-1[(113.74±19.62)ng/L vs.(94.36±16.58)ng/L],and significant rise in LVEF[(45.74±8.48)%vs.(50.78±8.34)%]and HDL-Clevel[(2.36±0.52)mmol/L vs.(2.93±0.57)mmol/L]in combined treatment group,P﹤0.01 all.During treatment,there was no significant difference in incidence rate of adverse reactions between two groups,P=0.539.Conclusion:Rhodiola grandiflora combined alprostadil possesses significant therapeutic effect on ACS.It can significantly improve cardiac function,regulate blood lipid metabolism and reduce inflammation with low incidence of adverse reactions,which is worth extending.