进展期胃癌术后腹腔热灌注化疗的研究进展

Research progress of intraperitoneal hyperthermic perfusion chemotherapy after advanced gastric cancer operation

胃癌为临床常见恶性肿瘤之一,外科手术是其重要治疗方案,进展期胃癌患者术后5年生存率较低,而术后癌灶复发成为影响患者预后的重要因素。随着国内医学水平不断发展,腹腔热灌注化疗技术得以不断改进,其在进展期胃癌患者术后辅助治疗中的应用日益广泛,长期临床实践表明预防性运用腹腔热灌注化疗可明显降低进展期胃癌术后复发率并提高其5年生存率,在改善患者生存质量及总体临床疗效方面的作用明确。本文旨在对中国进展期胃癌术后腹腔热灌注化疗的临床应用进展进行综述。

Gastric cancer is one of the most common clinical malignant tumors;surgery is an important treatment for it.The postoperative 5-year survival rate of patients with advanced gastric cancer is low;postoperative tumor recurrence is an important factor influencing the prognosis of patients.With the continuous development of domestic medicine,the technology of intraperitoneal hyperthermic perfusion chemotherapy is improved continuously,and is widely used in postoperative adjuvant therapy for patients with advanced gastric cancer.Long-term clinical practice shows that prophylactic use of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer could significantly reduce the recurrence rate of gastric cancer and improve the 5-year survival rate of patients.It plays a positive role in improving the quality of life of patients and overall clinical curative effect.In this review,the clinical application of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer in China was summarized.