低含量含砷水暴露对子代鼠生长和发育的影响

Effects of treatment of low arsenic-containing on growth and development of offspring mice

目的探讨饮水中低含量砷对小鼠生长和发育的影响。方法小鼠交配受孕后,给予洁净水(对照组)或10μg/L砷水(砷暴露组)饲养小鼠,评价母鼠生产结果、第1代幼鼠生长及健康状况。结果对照组和砷暴露组产仔数、孕龄及幼崽(包括存活和死亡)出生重量比较,差异无统计学意义(P>0.05)。出生后10和22天砷暴露组子代鼠体重低于对照组(P<0.05),表明出生后砷暴露组子代鼠生长发育减缓。妊娠第15.5天时,砷暴露组母鼠脂肪肝发生率为55.5%(5/9)高于对照组的0.0%(0/9)(P<0.05)。结论母鼠及其第1代子鼠暴露于低含量含砷水(含量符合我国当前饮用水标准)对第1代子鼠的关键生长发育期产生不良影响。

Objective To study the effect of low arsenic-containing in drinking water on growth and development of mice.Methods Clean water(control group)or 10μg/L arsenic water(arsenic exposure group)was fed to pregnant mice to evaluate the maternal results,growth and health of the first generation.Results There were no statistically significant difference in litter size,gestational age,and birth weight(including survival and death)between the control group and the arsenic exposure group(P >0.05).The weight of the offspring after the 10 days and 22 days in arsenic exposure group was lower than that in the control group(P<0.05),indicating that the growth and development of the offspring of the arsenic exposure group significantly were slowed down after birth.On the 15.5 day of gestation,the incidence of fatty liver was 55.5%(5/9)in maternal mice in arsenic exposure group,and that was 0%(0/9)in the control group.The incidence of fatty liver in the arsenic exposed group was higher than that in the control group(P<0.05).Conclusions Exposure to low arsenic content(in accordance with current drinking water standards in China)produces adverse outcomes in the critical growth and development period of the first generation mice.