期刊文献+

GLP-1受体激动剂与二型糖尿病的治疗现状 被引量:2

下载PDF
导出
摘要 二型糖尿病在全球的发病率以及其并发症所导致的致死率在不断蔓延,其治疗药物的研发迫在眉睫。GLP-1直接促进胰岛素的分泌,并且还可以抑制食欲以及抑制β细胞的凋亡,从而与二型糖尿病的发生发展息息相关。因此,GLP-1受体激动剂也成为最常与二甲双胍连用的二型糖尿病治疗药物。但临床研究表明,包括艾塞那肽、利拉鲁肽在内的GLP-1受体激动剂药物都存在一定的副作用影响。
作者 苏梓裔
出处 《现代商贸工业》 2019年第9期108-110,共3页 Modern Business Trade Industry
  • 相关文献

参考文献2

二级参考文献26

  • 1Trumper A, Trumper K, Horsch D. Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1 )-cells[J]. J Endocrinol,2002,174(2) : 233-246.
  • 2Lewis JT, Dayanandan B, Habener JF, et al. Glucose-depentent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist [J].Endocrinology, 2000,141 (10) :3710-3716.
  • 3Miyawaki K, Yamada Y, Ban N, et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity [J]. Nat Med, 2002,8(3) :738-742.
  • 4Hinke SA, Gelling RW, Pederson RA, et al. Dipeptidyl peptidaseⅣ-resistant [ D-Ala(2) ] glucose- dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats[J]. Diabetes, 2002,51 (3) :652-661.
  • 5Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes [J]. Diabetes Care, 2003,26 (10) :2929-2940.
  • 6Kim JG, Baggio LL, Bridon DP, et al. Development and characterization of a GLP-l-albumin conjugate which retains the ability to activate the GLP-I receptor in vivo [J]. Diabetes, 2003,52 (3) : 751-759.
  • 7Wang Q, Brubaker PL. Glucagon-like peptide-I treatment delays the onset of diabetes in 8 week-old db/db mice [J]. Diabetologia, 2002,45 (10) : 1263-1273.
  • 8Vilsboll T, Agerso H, Krarup T, et al. Similar elimination rates of glucagons-like peptide-1 in obese type 2 diabetic patients and healthy subjects[J]. J Clin Endocrinol Metab, 2003,88(2):220-224.
  • 9Verdich C, Flint A, Gutzwiller JP, et al. A meta-analysis of the effect of glucagons-like peptide-1 (7-36) amide on adlibitum energy intakein humans[J]. J Clin Endocrinol Metab , 2001,86(9):4382-4389.
  • 10Zander M, Madsbad S, Madsen JL, et al. Effect of 6-week course of glucagons-like peptide 1 on glycaemic control, insulin sensitivity,and beta-cell function in type 2 diabetes: a parallel-group study [J].Lancet, 2002,359 (4) :824-830.

共引文献10

同被引文献27

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部