氟比洛芬酯复合舒芬太尼用于宫颈癌患者围手术期镇痛效果及对免疫功能和肿瘤标志物的影响

Effect of flurbiprofen axetil combined with sufentanil on perioperative analgesia in patients with cervical cancer and its influence on immune function and serum tumor markers

目的研究氟比洛芬酯复合舒芬太尼用于宫颈癌患者围手术期镇痛效果及对免疫功能和血清肿瘤标志物的影响。方法将86例宫颈癌患者随机分成研究组和对照组,各43例。研究组患者应用氟比洛芬酯复合舒芬太尼进行镇痛,对照组患者采用舒芬太尼进行麻醉镇痛。比较两组患者的镇痛效果及手术前后免疫功能、血清肿瘤标志物变化。结果研究组患者在术后1 h、4 h、12 h、24 h、48 h的视觉模拟评分(VAS)评分均低于对照组,差异均有统计学意义(t分别=2.37、1.98、2.99、3.99、4.91,P均<0.05)。研究组患者术后1 d、2 d的免疫功能指标CD4、CD8、CD4/CD8水平高于对照组,差异均有统计学意义(t分别=3.46、2.72、2.82、9.32、3.49、4.56,P均<0.05)。研究组患者术后3 d、7 d的血清肿瘤标志物癌胚抗原(CEA)、鳞状细胞癌相关抗原(SCC-Ag)、糖类抗原125(CA125)水平低于对照组,差异均有统计学意义(t分别=7.17、3.54、5.06、11.67、7.47、7.28,P均<0.05)。结论宫颈癌患者围术期应用氟比洛芬酯复合舒芬太尼进行麻醉能有效减轻机体疼痛,减少对细胞免疫系统的影响,降低血清肿瘤标志物表达水平,提高手术效果。

Objective To study the analgesic effect of flurbiprofen axetil combined with sufentanil in patients with cervical cancer during perioperative period and its influence on immune function and serum tumor markers. Methods Totally 86 patients with cervical cancer were randomly divided into the study group and the control group with 43 cases in each. Patients in the study group were given flurbiprofen axetil combined with sufentanil for analgesia,while patients in the control group were given sufentanil for analgesia. The analgesic effect,immune function and serum tumor markers of the two groups were compared. Results The VAS scores of the study group at 1 h,4 h,12 h,24 h and 48 h after operation were significantly lower than those of the control group(t=2.37,1.98,2.99,3.99,4.91,P<0.05). The levels of CD4,CD8 and CD4/CD8 of the study group were significantly higher than those of the control group on the 1st and 2nd day after operation(t= 3.46,2.72,2.82,9.32,3.49,4.56,P<0.05). The levels of CEA,SCC-Ag,and CA125 of the study group were significantly lower than those of the control group on the 3rd and 7th day after operation(t= 7.17,3.54,5.06,11.67,7.47,7.28,P<0.05). Conclusion The application of flurbiprofen axetil combined with sufentanil anesthesia in patients with cervical cancer during perioperative period can effectively relieve pain,reduce the influence on cellular immune system,reduce the level of serum tumor markers,and improve the surgical effect.