摘要
目的探讨戒毒一号对甲基苯丙胺诱导的小鼠行为敏化的影响。方法分别采用单次给予甲基苯丙胺致小鼠高活动性及反复间断甲基苯丙胺处理建立甲基苯丙胺行为敏化小鼠模型,观察戒毒一号对甲基苯丙胺所致小鼠高活动性及其诱导的小鼠行为敏化的影响。结果戒毒一号低、高剂量灌胃给药后,对小鼠自发活动和甲基苯丙胺所致小鼠高活动性均无影响,却能显著抑制甲基苯丙胺诱导的小鼠行为敏化效应的形成、转化和表达。结论戒毒一号对甲基苯丙胺诱导的小鼠行为敏化的形成、转化和表达均有抑制作用,提示戒毒一号对甲基苯丙胺的精神依赖具有治疗作用。
Objective The aim of this study is to investigate the effects of Jieduyihao(JDYH)on the development,transfer and expression of methamphetamine(METH)-induced sensitization in mice.Methods The mice models of METH-induced hyperactivity with single dose administration and METH-induced behavioral sensitization with repeated intermittent administration were established.The effects of JDYH on the METH-induced hyperactivity and sensitization in mice were observed.Results Compared with the control group,the locomotor activity and hyperactivity of mice have no change after being treated with low-dose(14.12 g/kg)and high-dose(56.48 g/kg)of JDYH.Compared with the model group,the development,transfer and expression of METH-induced sensitization in JDYH treated mice were significantly suppressed.Conclusion JDYH can extraordinary inhibit the development,transfer and expression of METH-induced sensitization in mice,it suggests that JDYH may be a promising candidate for the management of METH addictions.
作者
李灿
唐利军
司远仁
肖华桥
茹琴
周梅
李超英
LI Can;TANG Lijun;SI Yuanren;XIAO Huaqiao;RU Qin;ZHOU Mei;LI Chaoying(Wuhan Institutes of Biomedical Sciences,Jianghan University,Wuhan 430056,Hubei,China;Hubei Provincial Key Laboratoryfor Applied Toxicology,Wuhan 430075,Hubei,China;Wuhan Wanji Psychiatric Hospital,Wuhan 430050,Hubei,China)
出处
《江汉大学学报（自然科学版）》
2019年第1期57-65,共9页
Journal of Jianghan University：Natural Science Edition
基金
武汉市首批黄鹤英才计划预防毒品复吸新药的研发与推广项目
应用毒理湖北省重点实验室开放课题
抗冰毒复吸中药组方的药效及毒理学临床前研究(1018-06010009)
江汉大学研究生科研创新基金项目(301004210001)
关键词
甲基苯丙胺
行为敏化
戒毒一号
methamphetamine(METH)
behavioral sensitization
Jieduyihao(JDYH)
