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脂肪酸转运在妊娠期肝内胆汁淤积胎盘组织中的表达研究进展

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摘要 妊娠期肝内胆汁淤积综合症(ICP)是妊娠特有的并发症。可导致胎儿窘迫、甚至胎死宫内严重妊娠结局。在胎盘进行的脂肪酸转运和代谢对胎儿生长发育至关重要。胎盘组织的脂肪酸转运蛋白,以及微小RNA,核受体参与脂肪酸转运蛋白转录和调控作用。因ICP中高胆汁酸和缺氧诱导因子-2α(HIF-2α)启动。使得脂肪酸转运和代谢难以维持妊娠,胎儿出现发育受限、甚至急性缺氧猝死。
作者 陈韵洁
出处 《医学食疗与健康》 2019年第2期201-201,203,共2页 Medical Diet and Health
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