4项指标检测在感染性疾病中的诊断价值

Diagnostic value of 4 indexes in infectious diseases

目的探讨降钙素原(PCT)、C反应蛋白(CRP)、白细胞计数(WBC)和中性粒细胞百分率(NEU%)在感染性疾病中的诊断价值。方法选取2016年8月至2018年8月该院收治的110例感染性疾病患者,根据细菌培养或病原体IgM抗体检测结果分为细菌感染组(56例)与非细菌感染组(54例),同时从健康体检者中设立对照组(60例),于用药前抽取各组人员的静脉血进行PCT、CRP、WBC和NEU%测定。结果细菌感染组的PCT、CRP、WBC和NEU%水平明显高于非细菌感染组及对照组,差异均有统计学意义(P<0.05)。非细菌感染组的PCT、WBC和NEU%水平与对照组比较,差异无统计学意义(P>0.05);非细菌感染组的CRP水平与对照组比较,差异有统计学意义(P<0.05)。对于细菌感染,CRP敏感度最高,PCT的特异度、约登指数、阳性预测值和阴性预测值均高于CRP、WBC和NEU%。结论 PCT、CRP、WBC和NEU%检测在感染性疾病的鉴别诊断中都有各自的应用价值,其中PCT对于细菌感染的诊断效能优于其他3项。

Objective To investigate the diagnostic value of procalcitonin(PCT),C-reactive protein(CRP),white blood cell count(WBC)and neutrophil percentage(NEU%)in infectious diseases.Methods One hundred and ten patients with infectious diseases in this hospital from August 2016 to August 2018 were selected and divided into the bacterial infection group(56 cases)and non-bacterial infection group(54 cases)according to the bacterial culture or pathogenic IgM antibody detection results.Meanwhile the control group(60 cases)was set up from the persons undergoing healthy physical examination.PCT,CRP,WBC and NEU%were measured by collecting venous blood before medication.Results The levels of PCT,CRP,WBC and NEU%in the bacterial infection group were significantly higher than those in the non-bacterial infection group and control group,and the differences were statistically significant(P<0.05).There were no statistical differences in the levels of PCT,WBC and NEU%between the non-bacterial infection group and control group(P >0.05).There was statistical difference in the CRP level between the non-bacterial infection group and control group(P<0.05).The sensitivity of CRP was the highest for bacterial infections.The specificity,Youden index,positive predictive value and negative predictive value of PCT were higher than those of CRP,WBC and NEU%.Conclusion PCT,CRP WBC and NEU%have their own application value in the differential diagnosis of infectious diseases,in which the diagnostic efficiency of PCT for bacterial infections is better than the other 3 indexes.