超分子水杨酸联合自拟消痤方治疗痤疮的临床研究

Clinical study of efficacy and safety of supramolecular salicylic acid combined with self-made elimilating acne formula for acne

目的评估超分子水杨酸联合自拟消痤方治疗轻、中度痤疮的治疗疗效。方法采用随机对照的方法将130例痤疮患者分为两组。治疗组65例予30%超分子水杨酸治疗,同时口服自拟消痤方;对照组65例予自拟消痤方口服,两组均予外擦夫西地酸乳膏。治疗8周后,评估患者皮损消退情况,同时记录不良反应。结果治疗结束后,治疗组有效率86.15%,对照组有效率66.15%,两组有显著性差异,具有统计学意义(P <0.05)。两组均未发生严重不良反应。结论超分子水杨酸联合自拟消痤方治疗轻、中度痤疮内治外调,起效快,效果好,患者依从性高,不良反应少,值得临床推广应用。

Objective To evaluate the efficacy and safety of supramolecular salicylic acid combined with self-made elimilating acne formula for mild to moderate acne.Methods A total of 130 acne patients were randomly divided into two groups.65 patients in treatment group were treated with supramolecular salicylic acid combined with self-made elimilating acne formula,while patients in control group were treated with self-made elimilating acne formula alone.The fusidic acid cream were used in both groups.The clinical efficacy was evaluated,and the adverse reactions were also recorded.Results After 8 weeks of treatment,the effective rates in treatment group and control group were 86.15%and 66.15%,respectively.There was significantly difference between two groups(P<0.05)There was no significant adverse reactions in either group.Conclusion Supramolecular salicylic acid combined with self-made elimilating acne formula for mild to moderate acne,is a safe internal and external treatment,with good efficacy and patient compliance,and worth more use in clinics.