不同严重程度的首发抑郁症患者的血清游离甲状腺素水平

Study on the level of free thyroxin in first-episode depressions with varied severity

目的探讨不同严重程度的抑郁症患者血清中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)水平。方法选择2017年9月一2018年4月在哈尔滨市第一专科医院的住院地首发抑郁症患者(105例),以及2017年10月本院参与体检的职工(57人)为研究对象,根据HAMD-24评分值将抑郁症患者分为3个亚组:轻度(33例)、中度(44例)、重度(28例)抑郁组。检测4组人群的FT3、FT4及TSH水平并比较。结果4组人群TSH差异无统计学意义(F=0.687,P=0.561);重度抑郁组的FT3均高于健康对照组、轻度和中度抑郁组(P﹤0.01);健康对照组、轻度和中度抑郁组3组之间FT3差异均无统计学意义(P﹥0.05);轻度、中度、重度抑郁组中FT4均高于健康对照组(P﹤0.05),但3个抑郁组间比较差异均无统计学意义(P﹥0.05)。结论血清中FT4相对水平的高低可能预示着是否存在抑郁的症状,而抑郁症血清中FT3相对水平的高低可能预示着病情的严重程度。

Objective To investigate the levels of free triiodothyronine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)in patients with depression of different severity.Methods The 105 first episode depression inpatients in the First Specialized Hospital of Harbin from September 2017 to April 2018 and the employees who participated in the physical examination in the hospital in October 2017 were selected as the research subjects.The depression patients were divided into 3 sub-groups according to the Hamilton Depression Scale(HAMD-24)score,namely mild depression group(n=33),moderate depression group(n=44)and severe depression group(n=28).The levels of FT3,FT4 and TSH were tested hy Autolumo A2000.Results There was no significant difference in TSH among the four groups(F=0.687,P=0.561).The FT3 level of the severe depression group was higher than that of the healthy group,the mild depression group and the m oderate depression group(P﹤0.01).There was no statistical significance in the difference of FT3 among the health group,mild depression group and moderate depression group(P﹥0.0 5).The level of VT4 of the 3 depression groups were all higher than that of the health group(P﹤0.05),however there was no statistical significance in the difference among the 3 depression groups(P﹥0.05).Conclusions The relative level of FT4 in serum may indicate the existence of depressive symptoms,while the relative level of FT3 in serum of depressive patients may indicate the severity of the disease.