摘要
化学药物的晶型研究已经成为国内外药学研究的热点问题。该文简要介绍药物的多晶型现象、晶型成因及研究意义,分析国际药物研发历程以及我国晶型药物发展特点,并从基础理论、技术方法、知识产权、研发监管等四个方面综述了我国化学药物晶型研究的现状与进展,为正确定位我国晶型药物研究水平以及明确晶型药物研发方向提供参考。
Polymorphism of chemical drugs has become a hot topic in pharmaceutical research at home and abroad.In this review,the phenomena,causes and significance of polymorphism were introduced briefly.The international drug development process and characteristics of the polymorphic drug development in our country were analyzed.Finally,the present situation and development in China was summarized from four aspects including the basic theory,technical methods,intellectual property rights and supervision.This paper can provide a reference for correct understanding the research level of polymorphic drugs in China and clarifying the direction of polymorphic drug research.
作者
杨世颖
周健
张丽
吕扬
杜冠华
YANG Shiying;ZHOU Jian;ZHANG Li;LYU Yang;DU Guanhua(Beijing Key Laboratory of Polymorphic Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Beijing Key Laboratory of Drug Targets Identification and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《医药导报》
CAS
北大核心
2019年第2期177-182,共6页
Herald of Medicine
基金
国家重点研发计划(2016YFC1000900)
中国医学科学院医学与健康科技创新工程(2016-I2M-3-007)
关键词
化学药物
晶型
知识产权
监管
Chemical drugs
Polymorphism
Intellectual property rights
Supervision
