1999—2017年中药治疗癌因性疲乏组方用药规律

Prescription Regularity of Chinese Herbs on Treating Cancer-related Fatigue in 1999-2017

目的应用中医传承辅助平台软件分析中药治疗癌因性疲乏的组方用药规律。方法收集1999—2017年中国期刊全文数据、万方数据库、维普数据库、中国生物医学文献数据库中所有中药治疗癌因性疲乏的文献,根据纳入和排除标准,筛选出符合条件的方剂,建立数据库,录入中医传承辅助平台,总结分析组方用药规律。结果共有33篇文献38首处方纳入分析,涉及中药108味,其中以温性、甘味、归脾经中药最多;白术、茯苓、炙甘草、黄芪、当归、陈皮、党参、地黄等使用频次较高;形成45个常用药物模式,演化出3或4味药的核心组合16个,聚类形成新处方5个。结论现代中医临床治疗癌因性疲乏注重健脾补肾,同时根据肿瘤治疗的独特性,更加强调中焦脾胃功能的调护,为临床辨证论治提供了有益参考。

Objective To analyze the prescription regularity of Chinese herbs in the treatment of cancer-related fatigue by TCM inheritance platform system software.Methods A total of documents on treating cancer-related fatigue by Chinese herbs were collected in CNKI database,Wanfang database,VIP database,CBM database from 1999 to 2017.According to the inclusion and exclusion criteria,the eligible prescriptions were selected to establish the database for summing up and analysing prescription regularity.Results A total of 33 articles were included in the analysis of 38 prescriptions,involving 108 kinds of Chinese herbs,of which the most common kinds were hot nature herb,sweetish taste,spleen meridian.Atractylodes,Poria,Licorice,Astragalus,Angelica,Tangerine peel,Codonopsis,Rehmannia had a high frequency of usage.It eventually formed 45 commonly used drug models,evolved into 16 core combinations of 3 to 4 herbs,and clustered into 5 new prescriptions.Conclusion The modern Chinese medicine in treatment of cancer-related fatigue is mainly focused on the spleen and kidney,what’s more,according to the unique nature of cancer treatment,more experts emphasize on the regulation of spleen and stomach function,which provides a useful reference for clinical syndrome differentiation and treatment.