银屑病皮肤及肠道微生态研究进展

Relationship of psoriasis with microecology of the skin and intestine

银屑病是一种主要表现为红斑、鳞屑的常见的慢性非感染性炎症性皮肤病。该病可被认为是一种系统性疾病,研究证实其与包括心血管疾病、肥胖、2型糖尿病,血脂异常、非酒精性脂肪肝、焦虑症、抑郁症和炎症性肠病等多种疾病存在联系。其发生发展与免疫反应密切相关,其中炎细胞浸润激活导致的T淋巴细胞免疫功能紊乱被证明是银屑病发病的关键环节。T淋巴细胞活化增殖,并在局部微环境中所存在的不同种类细胞因子调控下分化成不同亚群,从而参与银屑病发病。近年来研究者发现,局部微生物也在这一过程中发挥重要作用,本文就目前皮肤及肠道微生物在银屑病中的研究进展展开综述。

Psoriasis is a chronic,non-infective inflammatory dermatosis characterized by erythemas covered with scales.Psoriasis is considered as a systemic disease,and several studies have confirmed that it is associated with many other diseases,such as cardiovascular diseases,obesity,diabetes mellitus typeⅡ,dyslipidemia,nonalcoholic fatty liver disease,anxiety disorder,depression and inflammatory bowel disease.The occurrence and development of psoriasis is closely related to the immune response,and the immune dysfunction of T lymphocytes induced by the infiltration and activation of inflammatory cells has been confirmed as the key step in the pathogenesis of psoriasis.Various kinds of cytokines in the local microenvironment can promote the activation and proliferation of T lymphocytes,and regulate the differentiation of T lymphocytes into different subsets,which take an important part in the occurrence of psoriasis.In recent years,researchers have found that local microbes also play an important role in this process.Thus,this review summarizes the progress in the roles of human skin and gut microbiota in psoriasis.