摘要
小RNA病毒2B蛋白是一种非结构蛋白,其中部分已被证实隶属于viroporin家族,而viroporin是由病毒编码的一类小分子量疏水跨膜蛋白,可通过增大宿主细胞膜结构通透性扰乱其生理学功能而保证病毒完成生命周期。本文主要对小RNA病毒2B蛋白的viroporin特性及生物学功能进行阐释,以便加深对小RNA病毒复制及增殖的理解,并为抗病毒药物的研发提供参考。
The 2B protein of picornaviruses is a kind of non-structural protei n,some of which have been confirmedas belonging to the viroporin family.Viroporins are hydrophobic transmembrane proteins of low-molecularweight.They can ensure completion of the virus life-cycle by increasing the permeability of the cell-membrane structure of the host to disrupt physiological functions.Here,we explain the viroporin characteristics of viroporins,and biological functions of the 2B protein of picornavirus.In this way,we hope to deepen understanding of the replication and proliferation of picornavirus,and provide a reference for the development of antiviral drugs.
作者
叶倩
汪铭书
程安春
YE Qian;WANG Mingshu;CHENG Anchun(Avian Diseases Research Center.College of Veterinary Medicine,Sichuan Agricultural University Chengdu 611130,China;Key Laboratory of Animal Diseases and Human Health of Sichuan Province,Chengdu 611130,China;Institute of Preventive Veterinary Medicine,Sichuan Agricultural University Chengdu 611130,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2019年第1期134-141,共8页
Chinese Journal of Virology
基金
"十三五"国家重点研发计划(项目号:2017YFD0500800)
题目:水禽重要疫病免疫防控新技术研究
国家现代农业(水禽)产业技术体系专项(项目号:CARS‐42‐17)
题目:免疫抑制病防控
国家农业产业技术体系四川兽药创新团队专项(项目号:CARS‐SVDIP)
动物疫病与人类健康四川省重点实验室专项(项目号:2016JPT0004)~~
