KIAA1199基因在消化系统肿瘤中的作用

Role of KIAA1199 Gene in Digestive System Neoplasms

KIAA1199基因是HUGE数据库中的重要成员之一,通过表观遗传学等机制参与细胞内信号通路的转导,调控细胞生长、分化、凋亡、迁移等活动。近年研究发现,KIAA1199基因与肿瘤的发生、发展关系密切,在人类多种肿瘤尤其是消化系统肿瘤中的表达均异常升高,具有促进肿瘤细胞增殖、黏附、侵袭、迁移等作用。本文就KIAA1199基因在消化系统肿瘤中的作用作一综述。

KIAA1199 gene is an important member of the HUGE database,and is involved in the transduction of intracellular signaling pathway through epigenetic mechanism,regulating the cell growth,differentiation,apoptosis and migration.Recent studies showed that KIAA1199 gene is closely related to tumorigenesis and tumor development.The expression of KIAA1199 gene is highly upregulated in many types of tumor,especially in digestive system neoplasms,and having the effects of promoting proliferation,adhesion,invasion and migration of tumor cells.This article reviewed the role of KIAA1199 gene in digestive system neoplasms.