云南地区婴幼儿血管瘤发病因素调查

Investigation on the pathogenic factors of infantile hemangioma in Yunnan Province

目的探讨云南地区婴幼儿血管瘤发病的危险因素。方法随机选择确诊为IH的婴幼儿患者994例,与994名同年龄同地区的儿童进行对照研究。由专业调查员对其父母进行面对面的问卷调查(包括父母接触环境,职业,产前和围产期的特点)。数据采用SPSS 19. 0软件处理,采用二分类Logistic回归对所有变量进行单因素和多因素回归分析(向前LR,进入标准0.05,剔除标准0.10),检验水准a=0.05。结果对以上单因素回归分析选出的11个相关因素进行分析。正相关危险因素7个,性别(OR=2.641,95%CI:2.147～3.249)、保胎药(OR=2.797,95%CI:2.172～3.602)、孕期病毒感染(OR=10.233,95%CI:2.521～41.536)、室内外环境有害暴露(OR=2.038,95%CI:1.426～2.911)、母亲职业有害暴露(OR=3.396,95%CI:1.886～6.115)、宫内窒息(OR=15.060,95%CI:6.215～36.489)、脐带绕颈(OR=4.067,95%CI:3.050～5.422)。负相关危险因素4个,足月(OR=0.507,95%CI:0.348～0.741)、高龄产妇(OR=0.233,95%CI:0.161～0.339)、头胎(OR=0.433,95%CI:0.346～0.542)、滋补品(OR=0.550,95%CI:0.391～0.772)。结论本研究发现IH发病和父母孕前和孕期部分环境因素相关(孕前和怀孕早期预防流产的孕激素治疗)之间有密切的关系。

Objective To explore the risk factors of infantile hemangioma(IH)in Yunnan area.Methods 994 infants with IH were randomly selected and compared with 994 children of the same age and region.Face-to-face questionnaries of parents was conducted by professional investigators(including their exposure to the environment,occupation,prenatal and perinatal characteristics).The data was processed by SPSS 19.0 software.All variables were subjected to univariate and multivariate regression analysis using binary logistic regression(advanced LR,entry criterion 0.05,rejection criterion 0.10),test level a=0.05.Results 11 correlation factors were selected by regression analysis.7 positive related risk factors includes sex(OR=2.641,95%CI:2.147~3.249),medication during pregnancy(OR=2.797,95%CI:2.172~3.602),infection during pregnancy(OR=10.233,95%CI:2.521~41.536),outdoor exposure(OR=2.038,95%CI:1.426~2.911),occupational harmful exposure of mother(include petroleum,diesel,fertilizer,pesticide,leather,plastic adhesive,heavy metal,iatrogenic radiation,OR=3.396,95%CI:1.886~6.115),intrauterine asphyxia(OR=15.060,95%CI:6.215~36.489),umbilical cord bypass(OR=4.067,95%CI:3.050~5.422).There were 4 negative risk factors,full-term(OR=0.507,95%CI:0.348~0.741),older women(OR=0.233,95%CI:0.161~0.339),first child(OR=0.433,95%CI:0.346~0.542),tonics(OR=0.550,95%CI:0.391~0.772).Conclusion The present study found a closed relationship between IH and some environmental factors before and during pregnancy(progestin treatment for preventing abortion prepregnancy and early pregnancy).