哮喘患者气道炎症表型分布及肺功能分析

Phenotype distribution and lung function analysis of airway inflammation in asthmatic patients

目的探讨哮喘患者的气道炎症表型分布及肺功能指标情况。方法选择226例哮喘患者为研究对象,其中50例为重症哮喘,76例为普通哮喘,对比哮喘患者的气道炎症表型分布情况及患者肺功能指标情况。结果 226例哮喘患者中,嗜酸性粒细胞型最为常见,占36.73%,之后为中性粒细胞型(31.86%)、混合细胞型(22.12%)、寡细胞型(9.29%);重度哮喘患者中,中性粒细胞型患者肺功能相关指标均低于其它类型的重症患者(P<0.05)。结论在哮喘气道炎症表型中,最常见的表型为嗜酸性粒细胞型,其中中性粒细胞型的哮喘患者的肺功能最差。

Objective To explore the phenotype distribution and lung function indicators of airway inflammation in asthmatic patients.Methods 226 cases of asthma patients were chosen as the research objects,in which 50 cases of severe asthma,76 cases of asthma,to compare asthma airway inflammation phenotype distribution and lung function index.Results Among 226 asthma patients,eosinophilic granulocytes were the most common,accounting for 36.73%,followed by neutrophilic granulocytes(31.86%),mixed cell types(22.12%)and oligocytes(9.29%).Among patients with severe asthma,the lung function of neutrophil patients was lower than that of other severe patients(P<0.05).Conclusion Among asthmatic airway inflammatory phenotypes,the most common phenotype is eosinophilic granulocyte type,among which neutrophil asthmatic patients have the worst lung function.