血清肿瘤坏死因子-α在老年痛风性关节炎中的变化特点及意义

Changes and Significance of Serum Tumor Necrosis Factor-α in Elderly Patients with Gouty Arthritis

目的探讨老年痛风性关节炎患者血清肿瘤坏死因子-α(tumor necrosis factor-alpha, TNF-α)的变化特点及其意义。方法 2015年8月—2017年10月,选取年龄65岁及以上的痛风性关节炎患者,分为急性期组(n=56)和缓解期组(n=43)。记录所有患者的一般资料,检测白细胞计数、血尿酸、C反应蛋白(C-reactive protein, CRP)及TNF-α水平。结果急性期组患者CRP、白细胞计数及TNF-α均高于缓解期组(P<0.01)。急性期组患者血清TNF-α水平与血尿酸浓度无相关性,但TNF-α水平与白细胞计数和CRP呈正相关(r=0.785,P<0.001;r=0.646,P<0.01);缓解期组患者血清TNF-α水平与血尿酸浓度、白细胞计数及CRP均无相关性。结论 TNF-α在老年痛风性关节炎急性发作中发挥重要作用,且与炎症程度相关,与血尿酸浓度无关。

Objective To investigate the level of serum TNF-α,and explore its significance in elderly patients with gouty arthritis.Method A total of 99 cases(age≥65years)were recruited between August 2015 and October 2017and were divided into acute group(n=56)and remission group(n=43).General information of all patients was recorded,and leukocyte count,the levels of blood uric acid,C-reactive protein(CRP)and tumor necrosis factor alpha(TNF-α)were tested.Result Leukocyte count and levels of CRP and TNF-αwere significantly higher in the acute group(P<0.01)than in the remission group.There was no correlation between TNF-αlevel and Uric acid,but TNF-αlevel was positively correlated with leukocyte count and CRP level in the acute group(r=0.785,P<0.001;r=0.646,P<0.01).There was no correlation between TNF-αlevel and uric acid,leukocyte count and CRP in the remission group.Conclusion TNF-αplays an important role in acute inflammation of gout in the elderly,and may be associated with the degree of inflammation.