郁金散加减方对长白猪传染性胃肠炎治疗效果的研究

Study on the Therapeutic Effect of Modified Yujin Powder on Transimissible Gastroenteritis in Landrace Pigs

为了研究郁金散加减方对长白猪传染性胃肠炎的治疗效果,从张家口顺德猪场选取患有传染性胃肠炎的成年长白猪20头,随机分为郁金散加减方低剂量组、郁金散加减方高剂量组、西药组和对照组,每组各5头。郁金散加减方组每天灌服郁金散方剂,早晚各1次,低、高剂量组分别按6、7mL/kg体重给药;西药组每天灌服金刚乙胺,颈部皮下注射氟苯尼考,早晚各1次;对照组正常饲喂,不给药。7d后观察临床症状和生长性能,测定血常规、血清生化指标、血清免疫指标及抗氧化指标。结果表明:郁金散加减方组和西药组病猪反应灵敏,体温正常,进食量增加,粪便恢复正常。低、高剂量组和西药组治愈率分别为80%、90%和60%,郁金散加减方的治疗效果优于西药治疗。与对照组相比,高剂量组能极显著提高猪平均日增重(ADG)和平均日采食量(ADFI)(P<0.01),极显著降低料重比(P<0.01);3个给药组均能极显著降低血尿素氮(BUN)、丙二醛(MDA)和白细胞数量(WBC)(P<0.01),极显著提高血清钾(K)、总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)含量和总抗氧化能力(T-AOC)(P<0.01),但3组间差异不显著(P>0.05);高剂量组过氧化氢酶(CAT)活性极显著高于低剂量组、西药组和对照组(P<0.01)。表明郁金散加减方对长白猪传染性胃肠炎有较好的治疗效果,其中郁金散加减方高剂量组效果更好。

This experiment was to study the therapy of modified Yujin powder on transimissible gastroenteritis in Landrace pigs.20 adult Landrace pigs with gastroenteritis were selected from the Shunde farm in Zhangjiakou and randomly divided into low dose group,high dose group,western medicine group and control group with 5 pigs per group.The pigs in modified Yujin powdergroup were given Yujing powder once every morning and evening,6,7 mL/(kg·BW)for the low dose group and high dose group,respectively.The pigs in western medicine group were fed rimantadine and injected with florfenicol subcutaneously,once every morning and evening.The pigs in control group were fed normally and no medicine was given.After 7 d,the clinical symptoms and growth performance of the pigs were observed,and the blood routine,serum biochemical indexes,serum immune indexes and antioxidant indexes were measured.The results showed that Landrace pigs were sensitively reaction with normal body temperature,and the food intake was increased and feces returned to normal in the modified Yujin powder group.The healing rates were 80%,90%and 60%in low dose group,high dose group and western medicine group,respectively.The effects of modified Yujin powder was better than that in western medicine.The ADG and ADFI of high dose group were extremely significantly increased and the F/G was significantly reduced compared to control group(P<0.01).The contents of BUN,MDA and WBC in 3 drug delivery groups were extremely significantly lower than the control group(P<0.01),and the contents of K,TP,ALB,GLB and T-AOC in the 3 drug delivery groups were extremely significantly higher than that of control group(P<0.01),but there were no remarkable differences between the 3 groups(P >0.05).The serum CAT activity in the high dose group was extremely significantly higher than that in the low dose group,high dose group and control group(P<0.01).In conclusion,modified Yujin powder had a good therapeutic effect on the transimissible gastroenteritis in Landrace pigs,and the effect of the high dose group was better.