摘要
The morbidity of lung cancer has increased rapidly in recent decades.Non-small cell lung cancer(NSCLC)accounts for 80%-85% of total lung cancer cases.The molecular mechanism associated with NSCLC remains unclear.MicroRNAs(miRNAs)play an important role at the post-transcriptional level.NSCLC-associated pathways targeted by NSCLC-related miRNAs(NSCLC-miRNAs)have not been fully investigated.In a previous study,we have demonstrated 10 miRNAs are overexpressed in NSCLC and can be used as biomarkers for NSCLC diagnosis.In the present study,we found that five of the 10 miRNAs were downregulated in several common cancers.We analyzed the protein classes,molecular functions,biological functions,and signaling pathways targeted by the 5 NSCLC-related miRNAs and four main canonical pathways,identifying potential new targets for future clinical applications.
基金
grants from the National Natural Science Foundation of China(No.81372394,81602158,81602156,and 81572321)and Tianjin Health and Family Planning Commission Foundation of Science and Technology(15KG142).This work was also supported by CSCO-Merck Serono Oncology Research Fund(Y-MX2015-092)and Tianjin Science Foundation(No.15JCYBJC28200).The funders had no role in study design
in collection,analysis,and interpretation of data
in the writing of the report
and in the decision to submit this article for publication.
