血塞通汤剂对全脑缺血再灌注氧化应激作用的影响

Analysis of the Effects of XueSaiTong Decoction on Oxidative Stress of Total Cerebral Ischemia Reperfusion Injury

目的:探讨血塞通汤对全脑缺血再灌注氧化应激作用的影响。方法:将170例患者随机分为观察组和对照组,每组85例。对照组给予常规治疗,观察组在对照组治疗的基础上给予血塞通汤100 m L/次,2次/d治疗,2组均连续治疗14天,观察2组治疗后临床疗效、氧化应激指标、血液流变学指标及日常生活能力恢复情况。结果:总有效率观察组为95.3%,对照组为85.9%,2组比较差异有统计学意义(P<0.05)。谷胱苷肽氧化物酶(GSH-Px)与谷胱苷肽(GSH)含量治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。血浆比黏度、红细胞聚集指数、红细胞压积治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。日常生活能力改善情况观察组优于对照组,2组比较差异有统计学意义(P<0.05)。结论:血塞通汤能改善全脑缺血再灌注损伤患者氧化应激反应,降低血小板聚集,提高治疗效果,促进患者日常生活能力的恢复。

Objective:To discuss the effects of XueSaiTong decoction on oxidative stressof total cerebral ishchemia(TCI)reperfusion injury.Methods:All 170 patients were randomized into the observation group and the control group,85 cases each group,the control group accepted conventional therapy,and the observation group took XueSaiTong decoction on the foundation of the therapy the control group accepted,100 mL each time,twice each day,both groups were treated for 14 days consecutively,clinical effect,oxidative stress indexes,hemorheology indexes and tle recovery of ADL of both groups were observed after treating.Results:Total effective rate of the observation group was 95.3%,higher than 85.9%of the control group,and the difference had statistical meaning(P<0.05).The difference was statistically significant in the contents of GSH-Px and GSH within two groups before and after treating(P<0.05);the difference showed statistical meaning in the comparisons between both groups after treating(P<0.05).There was a significant difference in the comparisons of plasma ratio viscosity,erythrocyte aggregation index and hematocrit within two groups before and after treating(P<0.05);the difference had statistical meaning in these indexes between both groups after treating(P<0.05).The observation group was superior to the control group in the improvements ADL and the difference showed statistical meaning(P<0.05).Conclusion:XueSaiTong decoction could improve oxidative stress of the patients suffering TCI reperfusion injury,lower the aggregation index,raise therapeutic effects and promote the recovery of ADL.