脂必泰联合阿托伐他汀钙对冠心病患者血脂的影响

The Effects of ZhiBiTai Capsules and Atorvastatin Calcium on Blood Lipid of CHD Patients

目的:观察脂必泰联合阿托伐他汀钙对冠心病(CHD)患者血脂的影响。方法:将120例患者随机分为3组,每组40例:ZA-10组以脂必泰480 mg+阿托伐他汀钙10 mg治疗;A-20组以阿托伐他汀钙20 mg治疗;A-40组以阿托伐他汀钙40 mg治疗,3组均治疗8周。测量患者治疗前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及载脂蛋白ApoA1、ApoB100、心肌营养因子1(CT-1)、高敏C-反应蛋白(hs-CRP)、肌酸激酶同工酶(CK-MB)水平,观察不良反应发生情况。结果:治疗后TC、TG、LDL、ApoB100水平3组均显著下降(P<0.05);TG、LDL、ApoB100水平ZA-10组显著低于A-20、A-40组(P<0.05);3组患者载脂蛋白ApoA1水平比较无明显差异(P>0.05)。血清CT-1和hs-CRP水平3组均显著下降(P<0.05);CK-MB水平下降不明显(P>0.05),hs-CRP水平ZA-10组与A-20、A-40组比较差异显著(P<0.05)。不良反应发生率ZA-10组为17.5%,A-20组为25.0%,A-40组为30.0%,ZA-10组与A-40组比较,差异有统计学意义(P<0.05)。结论:脂必泰和阿托伐他汀钙联用可显著降低冠心病患者的TC、TG、LDL、ApoB100、hs-CRP水平,可减少阿托伐他汀钙的用量,且不良反应较少。

Objective:To observe the effects of ZhiBiTai and atorvastatin calcium on blood lipid of the patients with coronary heart disease(CHD).Methods:All 120 patients were randomized into three groups,40 cases each group:ZA-10 group were treated by ZhiBiTai capsules,480mg and atorvastatin calcium,10mg;A-20 group were given atorvastatin calcium,20mg;A-40 group atorvastatin calcium,40mg,three groups were treated for eight weeks.The levels of TC,TG,HDL and LDL ApoA1,ApoB100,cardiotrophin-1(CT-1),high sensitivity C-reactive protein(hs-CRP)and CK-MB of the patients were detected before and after treating,the incidence of adverse reaction was observed.Results:After treating,the levels of TC,TG,LDL,ApoB100 of three groups lowered notably(P<0.05);ZA-10 group was lower than A-20 and A-40 groups notably in the levels of TG,LDL and ApoB100(P<0.05);the obvious difference didn't existed in the comparison of the level of ApoA1 among three groups(P >0.05).The levels of CT-1 and hs-CRP of three groups decreased remarkably(P<0.05);the level of CK-MB decreased insignificantly(P >0.05),the difference was significant in the comparison of the levels of hs-CRP when ZA-10 group was compared with A-20 and A-40 groups(P<0.05).The incidences of adverse reaction of ZA-10 group,A-20 and A4-group were 17.5%,25.0%and 30.0%,the difference had statistical meaning when ZA-10 group was compared with A-40 group(P<0.05).Conclusion:The combination of ZhiBiTai capsules and atorvastatin calcium could decrease the levels of TC,TG,LDL,ApoB100 and hs-CRP with minor adverse reaction,and reduce the dose of atorvastatin calcium.