术前hs-CRP升高患者使用他汀类药物降低围手术期常见并发症的临床分析

Preoperative Stains Application for Perioperative Complications in Patients with Elevated Serum hs-CRP Level

目的探讨使用他汀类药物对外科围手术期hs-CRP升高患者指标的影响和围手术期常见并发症发生率的观察。方法选择175例外科围手术期合并高血压和或糖尿病和或冠心病且高敏C反应蛋白(hs-CRP)升高患者,随机分为三组,治疗组常规使用他汀类药物5天后行外科手术并复查高敏C反应蛋白(hs-CRP)并记录术后常见并发症发生率,强化组常规使用他汀类药物(加大剂量) 5天后行外科手术并复查高敏C反应蛋白(hs-CRP)并记录术后常见并发症发生率,对照组术后复查高敏C反应蛋白(hs-CRP)并记录术后常见并发症发生率。比较三组术前术后高敏C反应蛋白(hs-CRP)值变化及常见并发症发生率。结果治疗组、强化组患者术后高敏C反应蛋白(hs-CRP)有显著下降,差异有统计学意义(P<0.01);且围手术期常见并发症发生率明显下降,差异有统计学意义(P<0.05)。结论他汀类药物可有效降低围手术期患者hs-CRP水平及围手术期常见并发症发生率。

Objective To evaluate the efficacy of statins as premedicant on decreasing the risk of common perioperative complications in patients with high serum high-sensitivity C-reactive protein(hs-CRP).Methods 175 perioperative patients complicated with hypertension and/or diabetes mellitus and/or coronary heart disease and elevated serum hs-CRP level were chosen and randomly assigned to three groups.Treatment group received a regular dose of stains for consecutive 5 days before surgery.Intensive treatment group received stains with a strengthened dose for consecutive 5 days before surgery.Control group received no special intervention before surgery.Serum hs-CRP levels were reevaluated and the prevalence of common perioperative complications were recorded.Changes in the serum hs-CRP value prior and after surgery and complication rates were compared among three groups.Results Compared with controls,treatment group and intensive treatment group had significantly reduced hs-CRP after surgery((P﹤0.01),accompanied by simultaneous decreased complication rates(P﹤0.01).Conclusion Stains could effectively reduce serum hs-CRP and decrease risk of common perioperative complications in this study sample.