PGⅠ、PGⅡ、ET、CGRP在Hp感染的消化性溃疡患者血清中的变化及其意义

Changes and Significance of Serum PGⅠ,PG Ⅱ,ET and CGRP Levels in Patients with Peptic Ulcer Infected by Hp

目的探讨幽门螺杆菌(Hp)感染相关性消化性溃疡患者血清中胃蛋白酶原Ⅰ、Ⅱ(PGⅠ、PGⅡ)、内皮素(ET)、降钙素基因相关肽(CGRP)的变化及其临床意义。方法选取我院2016年1月至2017年3月确诊的消化性溃疡患者120例(PU组)、另选取60例健康对象作为对照组,检测并对比两组的血清PGⅠ、PGⅡ、ET、CGRP水平,并按照Hp感染检测结果、溃疡部位将PU组患者进行亚组分析。结果 PU组患者的血清PGⅠ、PGⅡ、ET水平均显著的高于对照组,PU组患者的血清CGRP水平均显著的低于对照组,差异有统计学意义(P<0. 05); Hp+组患者的血清PGⅠ、PGⅡ、ET水平均显著的高于Hp-组,Hp+组患者的血清CGRP水平均显著的低于Hp-组,差异有统计学意义(P<0. 05);胃溃疡患者的血清PGⅠ、PGⅡ、ET、CGRP水平与十二指肠溃疡患者比较差异无统计学意义(P>0. 05)。结论消化道溃疡患者的血清PGⅠ、PGⅡ、ET水平升高、CGRP水平降低,并且合并Hp感染会加重这一情况。

Objective To investigate the changes and clinical significance of serum pepsinogen I,II(PG I,PG II),endothelin(ET)and calcitonin gene related peptide(CGRP)in patients with peptic ulcer associated with Helicobacter pylori(Hp)infection.Methods We selected 120 patients with peptic ulcer diagnosed in our hospital from January 2016 to March 2017(PU group),and another 60 healthy people as control group.Serum PGI,PGII,ET and CGRP levels were detected and compared between the two groups,and subgroup analysis was performed on patients in the PU group according to Hp infection test results and ulcer site.Results The levels of serum PG I,PG II and ET in PU group were significantly higher than those in control group,while the levels of serum CGRP in PU group were significantly lower than those in control group,which were statistically significant(P﹤0.05);the levels of serum PG I,PG II and ET in Hp+group were significantly higher than those in Hp-group,and the levels of serum CGRP in Hp+group were significantly lower than those in Hp-group,which were statistically significant(P﹤0.05);the levels of serum PGI,PGII,ET and CGRP in patients with gastric ulcer were not significantly different from those in patients with duodenal ulcer(P﹥0.05).Conclusion The levels of serum PG I,PG II and ET increase and CGRP level decreases in patients with digestive tract ulcer,which can be aggravated by Hp infection.