消栓肠溶胶囊对急性脑梗死患者血清TGF-β_1和神经功能的影响

Influence of Xiaoshuan enteric-coated capsule on serum TGF-β_1 and neurological function in patients with acute cerebral infarction

目的:探讨消栓肠溶胶囊对急性脑梗死血清TGF-β_1及神经功能的影响。方法:选取96例急性脑梗死患者,按随机数字表法分为观察组(49例)和对照组(47例)。两组患者均按急性脑梗死进行常规治疗;观察组在对照组治疗基础上加用消栓肠溶胶囊治疗; 2周后比较两组患者血清TGF-β_1、NIHSS及Bathel指数变化。结果:治疗前两组患者血清TGF-β_1水平、NIHSS评分及Barthel指数比较,差异无统计学意义(P> 0. 05);治疗后,两组患者TGF-β_1水平较治疗前升高,差异有统计学意义(P <0. 05),NIHSS评分降低,差异有统计学意义(P <0. 05);观察组TGF-β_1水平明显高于对照组,差异有统计学意义(P <0. 01),NIHSS评分明显低于对照组,差异有统计学意义(P <0. 01);对照组治疗后Barthel指数有所升高,和治疗前比较,差异无统计学意义(P> 0. 05),而观察组患者Barthel指数升高明显,与治疗前和对照组比较,差异有统计学意义(P <0. 01)。结论:消栓肠溶胶囊可提高急性脑梗死患者的血清TGF-β_1水平,减轻炎性反应,改善神经功能,提高患者生存质量。

Objective To evaluate the influence of Xiaoshuan enteric-coated capsule on serum TGF-β1,neurological function in patients with acute cerebral infarction.Method 96 patients with acute cerebral infarction admitted to our hospital were randomly divided into observation group(49 cases)and control group(47 cases).The two groups were treated with the routine treatment of acute cerebral infarction,and the observation group was treated with Xiaoshuan enteric-coated capsule on the basis of the control group.After 2 weeks,the changes of serum TGF-β1,NIHSS and Bathel index were compared between the two groups.Results Serum TGF-β1 level,NIHSS score and Barthel index between the two groups had no statistically significant difference before treatment before treatment(P >0.05).After treatment,the level of TGF-β1 in the two groups was higher than that before the treatment(P<0.05)and NIHSS score decreased(P<0.05).The level of TGF-β1 of observation group were significantly higher than that of control group(P<0.01),and the NIHSS score was significantly lower than that of control group(P<0.01).The Barthel index of control group rised,but there were no significant difference compared with before(P >0.05).But the Barthel index of the observation group increased significantly,which was significantly different from that before treatment and the control group(P<0.01).Conclusion Xiao Shuan enteric-coated capsule can improve serum TGF-β1 level,reduce inflammatory reaction,improve neurological function and improve the quality of life in patients with acute cerebral infarction.