摘要
本文对目前国内外研究报道的部分海洋动物蛋白药物进行了归纳总结,分别介绍了海兔毒素、芋螺毒素、海鞘毒素、海绵活性多肽、海葵活性多肽及其结构类似物、衍生物的来源、结构、药理、分子靶标、临床试验研究现状和发展瓶颈,以期为开发强效、稳定的新型海洋药物提供参考。
The development of marine animal-derived protein drugs were reviewed in this paper.The sources,structures,pharmacology,molecular targets,current clinical research status and development bottlenecks of dolastatins,conotoxins,sphingomyelin toxins,sponge bioactive peptides,sea anemone bioactive peptides and their analogues,as well as derivatives were summarized,in order to provide broad perspective for the development of powerful,stable and novel marine drugs.
作者
潘南
刘智禹
PAN Nan;LIU Zhiyu(Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Fisheries Research Institute of Fujian,Xiamen 361013,China;Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources,Xiamen 361013,China)
出处
《渔业研究》
2019年第1期75-86,共12页
Journal of Fisheries Research
基金
福建省自然科学基金计划项目(2016J01344)
福建省省属公益类科研院所基本科研专项(2018R1003-11)
福建省海洋生物增养殖与高值化利用重点实验室项目(2015fjscq01)
关键词
海洋动物蛋白
药物及临床应用
研究进展
marine animal-derived protein
pharmaceutical and clinical application
research progress